Department of Head and Neck Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University.
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Int J Surg. 2024 Sep 1;110(9):5585-5594. doi: 10.1097/JS9.0000000000001636.
Limited studies have explored the joint effect of physical activity (PA) and dietary quality (DQ) on the mortality outcomes of the cancer population. The authors aim to investigate the separate and joint prognostic effect of PA and DQ on the survival of US cancer survivors.
Data of cancer survivors ( n =3007, representing 22 million cancer survivors) were from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018. PA was assessed using the self-reported Global Physical Activity Questionnaire (GPAQ) and DQ was evaluated through the Health Eating Index-2015 (HEI-2015). Kaplan-Meier (KM) curves and the Cox proportional hazard model were used to evaluate the associations between separate and joint prognostic effects of PA and DQ with mortality outcomes among cancer survivors.
In the joint analyses, cancer survivors with sufficiently active PA (≥600 MET-min/week) and qualified DQ (≥60) presented reduced risks of all-cause mortality (HR 0.45, 95% CI: 0.35-0.59) as compared with each lifestyle intervention separately. Meanwhile, the joint effects of either insufficiently or sufficiently active PA (>0 MET-min/week) and qualified DQ (≥60) were associated with lower risks for cancer (HR 0.60, 95% CI: 0.40-0.90) and noncancer mortality (HR 0.43, 95% CI: 0.32-0.59).
Our study highlights the combination of active PA and qualified DQ was strongly associated with reduced mortality risk of cancer survivors. Our findings might help to refine the lifestyle intervention recommendations for this population.
有限的研究探讨了体力活动（PA）和饮食质量（DQ）对癌症患者死亡率结果的联合影响。作者旨在调查 PA 和 DQ 对美国癌症幸存者生存的单独和联合预后影响。
癌症幸存者的数据（n=3007，代表 2200 万癌症幸存者）来自于 2007 年至 2018 年期间的国家健康和营养检查调查（NHANES）。使用自我报告的全球体力活动问卷（GPAQ）评估 PA，通过 2015 年健康饮食指数（HEI-2015）评估 DQ。使用 Kaplan-Meier（KM）曲线和 Cox 比例风险模型评估 PA 和 DQ 单独和联合的预后效应对癌症幸存者死亡率结局的关联。
在联合分析中，具有足够活跃 PA（≥600 MET-min/周）和合格 DQ（≥60）的癌症幸存者与每种生活方式干预单独相比，全因死亡率的风险降低（HR 0.45，95%CI：0.35-0.59）。同时，无论是不活跃还是足够活跃 PA（>0 MET-min/周）和合格 DQ（≥60）的联合作用，都与癌症（HR 0.60，95%CI：0.40-0.90）和非癌症死亡率（HR 0.43，95%CI：0.32-0.59）的较低风险相关。
我们的研究强调了活跃 PA 和合格 DQ 的结合与癌症幸存者死亡率风险降低密切相关。我们的研究结果可能有助于为该人群制定更精确的生活方式干预建议。
