Institute for Infection Prevention and Control, University of Freiburg - Medical Center, Freiburg, Germany.
Laboratory of Medical Microbiology, University of Antwerp, Antwerp, Belgium.
Nat Commun. 2024 Jun 14;15(1):5092. doi: 10.1038/s41467-024-49349-z.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) are of particular concern due to the spread of antibiotic resistance genes associated with mobile genetic elements. In this study, we collected 687 carbapenem-resistant strains recovered among clinical samples from 41 hospitals in nine Southern European countries (2016-2018). We identified 11 major clonal lineages, with most isolates belonging to the high-risk clones ST258/512, ST101, ST11, and ST307. bla was the most prevalent carbapenemase-encoding gene (46%), with bla present in 39% of isolates. Through the combination and comparison of this EURECA collection with the previous EuSCAPE collection (2013-2014), we investigated the spread of high-risk clones circulating in Europe exhibiting regional differences. We particularly found bla ST258/512 in Greece, Italy, and Spain, bla ST101 in Serbia and Romania, bla ST11 in Greece, and bla ST14 in Türkiye. Genomic surveillance across Europe thus provides crucial insights for local risk mapping and informs necessary adaptions for implementation of control strategies.
耐碳青霉烯类肺炎克雷伯菌（CRKP）引起了人们的特别关注，因为其与移动遗传元件相关的抗生素耐药基因正在传播。在这项研究中，我们收集了来自 9 个南欧国家的 41 家医院的临床样本中分离的 687 株耐碳青霉烯类肺炎克雷伯菌。我们鉴定出 11 个主要的克隆谱系，大多数分离株属于高风险克隆 ST258/512、ST101、ST11 和 ST307。bla 是最常见的碳青霉烯酶编码基因（46%），其中 39%的分离株携带 bla 。通过将这个 EURECA 集合与之前的 EuSCAPE 集合（2013-2014 年）进行组合和比较，我们研究了在欧洲流行的具有区域差异的高风险克隆的传播情况。我们特别在希腊、意大利和西班牙发现了 bla ST258/512，在塞尔维亚和罗马尼亚发现了 bla ST101，在希腊发现了 bla ST11，在土耳其发现了 bla ST14。因此，欧洲的全基因组监测为当地风险测绘提供了关键的见解，并为实施控制策略提供了必要的适应性调整。
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