Department of Cardiology, First Hospital of Shanxi Medical University, Taiyuan, China.
First Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Eur J Neurol. 2024 Sep;31(9):e16382. doi: 10.1111/ene.16382. Epub 2024 Jun 15.
Hypertension significantly contributes to stroke. Previous research has indicated a connection between daytime napping and stroke. Research on the connection between daytime napping duration and first stroke in hypertensive individuals is lacking nevertheless.
This research, which ran from 24 August 2013 to 31 December 2022, recruited 11,252 individuals with hypertension and without a history of stroke from the China Stroke Primary Prevention Trial. To determine the relationship between daytime napping duration and stroke onset in hypertensive individuals, we conducted analyses for threshold effects, multivariate-adjusted Cox proportional hazard regression models, and Kaplan-Meier survival curves.
The duration of daytime napping (<75 min) was positively correlated with stroke risk; beyond 75 min, the risk did not increase further. When compared to hypertensive individuals who napped for 1-30 min, daytime napping 31-60 min (hazard ratio [HR] = 1.27, 95% confidence interval [CI] = 1.06-1.53) and >60 min (HR = 1.37, 95% CI = 1.14-1.65) were substantially related with a greater risk of first stroke. Additionally, this correlation was absent in cases of hemorrhagic stroke, but present in cases of ischemic stroke, specifically for hypertensive individuals who napped for 31-60 min or >60 min (p < 0.05). Kaplan-Meier survival curves displayed that hypertensive individuals who extended daytime napping had an elevated incidence of stroke.
Hypertensive individuals who take longer daytime naps (>30 min) are at an elevated risk of stroke onset, particularly ischemic stroke, irrespective of other factors.
高血压是导致中风的重要因素。先前的研究表明,白天小睡与中风之间存在关联。然而,目前缺乏关于高血压患者白天小睡持续时间与首次中风之间关系的研究。
本研究于 2013 年 8 月 24 日至 2022 年 12 月 31 日进行,共纳入 11252 例无中风病史的高血压患者,这些患者均来自中国脑卒中一级预防试验。为了确定高血压患者白天小睡持续时间与中风发作之间的关系,我们进行了阈效应分析、多变量调整的 Cox 比例风险回归模型和 Kaplan-Meier 生存曲线分析。
白天小睡持续时间(<75 分钟)与中风风险呈正相关;超过 75 分钟后,风险不再进一步增加。与白天小睡 1-30 分钟的高血压患者相比,白天小睡 31-60 分钟(危险比 [HR] = 1.27,95%置信区间 [CI] = 1.06-1.53)和>60 分钟(HR = 1.37,95% CI = 1.14-1.65)与首次中风的风险显著增加相关。此外,这种相关性在出血性中风中不存在,但在缺血性中风中存在,特别是对于白天小睡 31-60 分钟或>60 分钟的高血压患者(p<0.05)。Kaplan-Meier 生存曲线显示,白天小睡时间延长的高血压患者中风发生率升高。
白天小睡时间较长(>30 分钟)的高血压患者中风发病风险升高,尤其是缺血性中风,与其他因素无关。