Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Atherosclerosis. 2024 Aug;395:117609. doi: 10.1016/j.atherosclerosis.2024.117609. Epub 2024 May 31.
Previous studies have shown that skin autofluorescence (SAF), measured with an advanced glycation end product (AGE) reader, estimates the accumulation of AGEs in tissues. SAF is predictive of incident type 2 diabetes, cardiovascular disease (CVD), and CV mortality in the general population. Studies in diabetic mice have shown that activation of the receptor for AGEs in hematopoietic progenitor cells increases blood neutrophils and monocytes, impairing atherosclerosis regression. We asked whether SAF is associated with blood neutrophil and monocyte counts in the general population, and whether this was moderated by prediabetes, diabetes, and sex.
We examined the associations between SAF and blood neutrophil/monocyte counts in participants of the Lifelines cohort (n = 58,923: n = 24,382 men, and n = 34,541 women), a prospective population-based cohort from the North of the Netherlands, employing multivariable regression analyses.
SAF positively associated with blood neutrophil and monocyte counts in the whole cohort. The positive association between SAF and monocyte, but not neutrophil, counts was moderated by prediabetes and diabetes. Positive associations between SAF and blood neutrophil and monocyte counts were moderated by male sex. Moreover, three-way interaction analyses revealed that the positive associations between SAF and neutrophil and monocyte counts were moderated by prediabetes, but not diabetes, in male sex.
SAF is positively associated with blood neutrophil and monocyte counts in the general population, especially in men with prediabetes. This may contribute to the increased CV risk in men with prediabetes.
先前的研究表明，使用先进糖基化终产物（AGE）读数测量的皮肤自发荧光（SAF）估计组织中 AGE 的积累。SAF 可预测普通人群中 2 型糖尿病、心血管疾病（CVD）和心血管死亡率的发生。在糖尿病小鼠中的研究表明，在造血祖细胞中激活 AGE 受体可增加血液中性粒细胞和单核细胞，从而损害动脉粥样硬化的消退。我们想知道 SAF 是否与普通人群中的血液中性粒细胞和单核细胞计数有关，以及这种关系是否受到糖尿病前期、糖尿病和性别的调节。
我们在 Lifelines 队列（n=58923：男性 n=24382，女性 n=34541）的参与者中检查了 SAF 与血液中性粒细胞/单核细胞计数之间的关联，这是一个来自荷兰北部的前瞻性人群队列，采用多变量回归分析。
SAF 与整个队列中的血液中性粒细胞和单核细胞计数呈正相关。SAF 与单核细胞计数之间的正相关，而不是中性粒细胞计数，受糖尿病前期和糖尿病的调节。SAF 与血液中性粒细胞和单核细胞计数之间的正相关受男性性别的调节。此外，三向相互作用分析显示，SAF 与中性粒细胞和单核细胞计数之间的正相关在男性中受糖尿病前期调节，但不受糖尿病调节。
SAF 与普通人群中的血液中性粒细胞和单核细胞计数呈正相关，尤其是在糖尿病前期的男性中。这可能导致糖尿病前期男性的心血管风险增加。
