Assessing the prognostic value of mutation combined with tumor size in stage I-II non-small cell lung cancer: a retrospective analysis.

BACKGROUND

mutation status is a well-established independent prognostic factor in advanced non-small cell lung cancer (NSCLC), yet its role in early-stage disease is unclear. Here, we investigate the prognostic value of combining survival data on mutation status and tumor size in stage I-II NSCLC.

METHODS

We studied the combined impact of mutational status and tumor size on overall survival (OS) in patients with stage I-II NSCLC. We performed a retrospective study including 310 diagnosed patients with early (stage I-II) NSCLCs. All molecularly assessed patients diagnosed with stage I-II NSCLC between 2016-2018 in the Västra Götaland Region of western Sweden were screened in this multi-center retrospective study. The primary study outcome was overall survival.

RESULTS

Out of 310 patients with stage I-II NSCLC, 37% harbored an activating mutation in the gene. Our study confirmed staging and tumor size as prognostic factors. However, mutational status was not found to impact OS and there was no difference in the risk of death when combining mutational status and primary tumor size.

CONCLUSIONS

In our patient cohort, mutations in combination with primary tumor size did not impact prognosis in stage I-II NSCLC.