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特发性肺纤维化发病机制相关信号通路的研究现状。

Current state of signaling pathways associated with the pathogenesis of idiopathic pulmonary fibrosis.

机构信息

School of Medicine, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu, 224005, China.

出版信息

Respir Res. 2024 Jun 17;25(1):245. doi: 10.1186/s12931-024-02878-z.

Abstract

Idiopathic Pulmonary Fibrosis (IPF) represents a chronic and progressive pulmonary disorder distinguished by a notable mortality rate. Despite the elusive nature of the pathogenic mechanisms, several signaling pathways have been elucidated for their pivotal roles in the progression of this ailment. This manuscript aims to comprehensively review the existing literature on the signaling pathways linked to the pathogenesis of IPF, both within national and international contexts. The objective is to enhance the comprehension of the pathogenic mechanisms underlying IPF and offer a scholarly foundation for the advancement of more efficacious therapeutic strategies, thereby fostering research and clinical practices within this domain.

摘要

特发性肺纤维化(IPF)是一种慢性且进行性的肺部疾病,其死亡率相当高。尽管其发病机制尚不清楚,但已经确定了几种信号通路,这些信号通路在该疾病的进展中起着关键作用。本文旨在全面回顾国内外有关与 IPF 发病机制相关的信号通路的现有文献,旨在提高对 IPF 发病机制的认识,并为开发更有效的治疗策略提供学术基础,从而促进该领域的研究和临床实践。

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