Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Curr Biol. 2024 Jun 17;34(12):R565-R567. doi: 10.1016/j.cub.2024.04.074.
Turning centromere DNA into a mechanical spring is central to the fidelity of chromosome segregation. A recent study shows how centromere DNA loops and partitioning cohesin and condensin convert centromeres and pericentromeres into bipartite bottlebrushes.
将着丝粒 DNA 转化为机械弹簧是染色体分离保真度的核心。最近的一项研究表明,着丝粒 DNA 环化以及分配黏合蛋白和凝聚素如何将着丝粒和着丝粒周围区域转化为二联体瓶刷。