Faculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland.
Department of Human Morphology and Embryology, Division of Histology and Embryology, Faculty of Medicine, Wroclaw Medical University, T. Chalubińskiego 6a, 50-368 Wroclaw, Poland.
Int J Mol Sci. 2024 Jun 5;25(11):6206. doi: 10.3390/ijms25116206.
Cancer diseases constitute a major health problem which leads to the death of millions of people annually. They are unique among other diseases because cancer cells can perfectly adapt to the environment that they create themselves. This environment is usually highly hostile and for normal cells it would be hugely difficult to survive, however neoplastic cells not only can survive but also manage to proliferate. One of the reasons is that they can alter immunological pathways which allow them to be flexible and change their phenotype to the one needed in specific conditions. The aim of this paper is to describe some of these immunological pathways that play significant roles in gynecologic neoplasms as well as review recent research in this field. It is of high importance to possess extensive knowledge about these processes, as greater understanding leads to creating more specialized therapies which may prove highly effective in the future.
癌症是一个严重的健康问题,每年导致数百万人死亡。与其他疾病不同,癌细胞可以完美地适应它们自己创造的环境。这种环境通常极具敌意,正常细胞很难在其中生存,但肿瘤细胞不仅能够存活,还能够增殖。原因之一是它们可以改变免疫途径,使它们具有灵活性,并将表型改变为特定条件下所需的表型。本文的目的是描述在妇科肿瘤中起重要作用的一些免疫途径,并回顾该领域的最新研究。拥有这些过程的广泛知识非常重要,因为更深入的了解会导致创建更具针对性的治疗方法,这些方法在未来可能会非常有效。