Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Department of Public Health, University of Naples Federico II, 80131 Naples, Italy.
Int J Mol Sci. 2024 Jun 5;25(11):6224. doi: 10.3390/ijms25116224.
Breast cancers (BCs) are solid tumors composed of heterogeneous tissues consisting of cancer cells and an ever-changing tumor microenvironment (TME). The TME includes, among other non-cancer cell types, immune cells influencing the immune context of cancer tissues. In particular, the cross talk of immune cells and their interactions with cancer cells dramatically influence BC dissemination, immunoediting, and the outcomes of cancer therapies. Tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) represent prominent immune cell populations of breast TMEs, and they have important roles in cancer immunoescape and dissemination. Therefore, in this article we review the features of TILs, TAMs, and MDSCs in BCs. Moreover, we highlight the mechanisms by which these immune cells remodel the immune TME and lead to breast cancer metastasis.
乳腺癌（BC）是由异质性组织组成的实体瘤，这些组织包括癌细胞和不断变化的肿瘤微环境（TME）。TME 包括除其他非癌细胞类型外，还包括影响癌症组织免疫环境的免疫细胞。特别是，免疫细胞的串扰及其与癌细胞的相互作用，极大地影响了 BC 的扩散、免疫编辑和癌症治疗的结果。肿瘤浸润淋巴细胞（TILs）、肿瘤相关巨噬细胞（TAMs）和髓系来源的抑制细胞（MDSCs）是乳腺 TME 中主要的免疫细胞群体，它们在癌症免疫逃逸和扩散中起着重要作用。因此，在本文中，我们综述了 TILs、TAMs 和 MDSCs 在 BC 中的特征。此外，我们还强调了这些免疫细胞重塑免疫 TME 并导致乳腺癌转移的机制。
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