Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Nutrients. 2024 May 31;16(11):1727. doi: 10.3390/nu16111727.
Short-chain fatty acids (SCFAs) have been reported to be associated with the pathogenesis of irritable bowel syndrome (IBS), but the results are conflicting.
Here, a systematic review of case-control studies detecting fecal SCFAs in IBS patients compared with healthy controls (HCs) and self-controlled studies or randomized controlled trials (RCTs) investigating fecal SCFA alterations after interventions were identified from several databases.
A systematic search of databases (PubMed, Web of Science, and Embase) identified 21 studies published before 24 February 2023. Data extractions: Three independent reviewers completed the relevant data extraction.
It was found that the fecal propionate concentration in IBS patients was significantly higher than that in HCs, while the acetate proportion was significantly lower. Low-FODMAP diets significantly reduced the fecal propionate concentration in the IBS patients while fecal microbiota transplantation and probiotic administration did not significantly change the fecal propionate concentration or acetate proportion.
The results suggested that the fecal propionate concentration and acetate proportion could be used as biomarkers for IBS diagnosis. A low-FODMAP diet intervention could potentially serve as a treatment for IBS while FMT and probiotic administration need more robust trials.
短链脂肪酸（SCFAs）已被报道与肠易激综合征（IBS）的发病机制有关，但结果存在争议。
本研究通过系统检索比较 IBS 患者与健康对照（HC）粪便 SCFA 的病例对照研究，以及干预后粪便 SCFA 变化的自身对照研究或随机对照试验（RCT），从多个数据库中确定了 21 项研究。
系统检索数据库（PubMed、Web of Science 和 Embase），检索时间截至 2023 年 2 月 24 日。数据提取：由 3 位独立的评审员完成相关数据提取。
结果发现，IBS 患者粪便中丙酸浓度明显高于 HCs，而乙酸比例明显降低。低 FODMAP 饮食可显著降低 IBS 患者粪便中丙酸浓度，而粪便微生物群移植和益生菌给药并未显著改变粪便丙酸浓度或乙酸比例。
研究结果表明，粪便丙酸浓度和乙酸比例可作为 IBS 诊断的生物标志物。低 FODMAP 饮食干预可能是治疗 IBS 的一种方法，而 FMT 和益生菌给药需要更多的临床试验。
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