School of Health Science and Engineering, Shanghai Engineering Research Center of Food Microbiology, University of Shanghai for Science and Technology, Shanghai 200093, China.
Naval Medical Center, Naval Medical University, Shanghai 200433, China.
Nutrients. 2024 Jun 4;16(11):1761. doi: 10.3390/nu16111761.
Certain workplaces, like deep-sea voyages, subject workers to chronic psychological stress and circadian rhythm disorders due to confined environments and frequent shifts. In this study, participants lived in a strictly controlled confined environment, and we analyzed the effects of a confined environment on gut microbiota and metabolites. The results showed that living in confined environments can significantly alter both the gut microbiota and the gut metabolome, particularly affecting lipid metabolism pathways like glycerophospholipid metabolism. There was a significant reduction in the abundance of and , while , , and showed significant increases. An association analysis revealed a strong correlation between changes in the gut microbiota and the metabolome. Four upregulated lipid metabolites may serve as biomarkers for damage induced by confined environments, and certain gut microbiota alterations, such as those involving and , could be potential psychobiotics or therapeutic targets for enhancing mental health in a confined environment.
某些工作场所，如深海航行，由于环境受限和频繁轮班，使工人长期面临心理压力和昼夜节律紊乱。在这项研究中，参与者生活在严格控制的封闭环境中，我们分析了封闭环境对肠道微生物群和代谢物的影响。结果表明，生活在封闭环境中会显著改变肠道微生物群和肠道代谢组，特别是影响甘油磷脂代谢等脂质代谢途径。和的丰度显著降低，而、、和则显著增加。关联分析显示，肠道微生物群和代谢组的变化之间存在很强的相关性。四种上调的脂质代谢物可能作为由封闭环境引起的损伤的生物标志物，某些肠道微生物群的改变，如涉及和的改变，可能是增强封闭环境下心理健康的潜在益生菌或治疗靶点。
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