Xiangya School of Public Health, Central South University, Changsha 410078, China.
Nutrients. 2024 Jun 4;16(11):1763. doi: 10.3390/nu16111763.
There is increasing evidence suggesting that serum neurofilament light chain (sNfL) levels can be used as biomarkers for axonal injury. Retinol is recognized for its significant involvement in nervous system function, but the precise connection between dietary retinol and sNfL levels remains uncertain.
Our objective was to investigate the relationship between dietary retinol intake and sNfL, and to find an optimal retinol intake level for neurological health.
In the National Health and Nutrition Examination Survey (NHANES), conducted from 2013 to 2014, a cohort of 1684 participants who met the criteria were selected for the study. sNfL levels were measured from stored serum samples using a novel high-throughput immunoassay platform from Siemens Healthineers. Assessment of dietary retinol intake was performed by a uniformly trained interviewer through a 24 h dietary recall method. A generalized linear model was evaluated to assess the correlation between dietary retinol intake and sNfL concentrations. Furthermore, the nonlinear association between the two is further explored using restricted cubic spline (RCS) analysis.
Upon adjusting for potential confounders, a 10% increase in dietary retinol intake was associated with a 3.47% increase in sNfL levels (95% CI: 0.54%, 6.49%) across all participants. This relationship was more pronounced in specific subgroups, including those under 60 years of age, non-obese, impaired estimated glomerular filtration rate (eGFR), and non-diabetic. In subgroup analysis, among those younger than 60 years of age (percent change: 3.80%; 95% CI: 0.43%, 7.28%), changes were found in non-obese participants (percent change: 6.28%; 95% CI: 2.66%, 10.02%), those with impaired eGFR (percent change: 6.90%; 95% CI: 1.44%, 12.65%), and non-diabetic patients (percentage change: 4.17%; 95% CI: 1.08%, 7.36%). RCS analysis showed a linear relationship between dietary retinol intake and sNfL levels. Furthermore, the positive correlation between the two was more significant after the inflection point, according to piecewise linear analysis.
This current investigation uncovered a J-shaped relationship between dietary retinol and sNfL levels, suggesting that axonal damage can occur when dietary retinol intake increases more than a specific threshold. These findings need to be further confirmed in future prospective studies to determine the precise intake level that may trigger axonal injury.
越来越多的证据表明，血清神经丝轻链（sNfL）水平可用作轴突损伤的生物标志物。视黄醇因其对神经系统功能的显著影响而受到认可，但饮食中视黄醇与 sNfL 水平之间的确切联系仍不确定。
我们的目的是研究饮食中视黄醇的摄入与 sNfL 之间的关系，并找到对神经系统健康最理想的视黄醇摄入水平。
在 2013 年至 2014 年进行的全国健康和营养检查调查（NHANES）中，选择了符合标准的 1684 名参与者进行研究。使用西门子健康公司的新型高通量免疫分析平台从储存的血清样本中测量 sNfL 水平。通过经过统一培训的访谈者通过 24 小时膳食回忆法评估饮食中视黄醇的摄入量。使用广义线性模型评估饮食中视黄醇摄入与 sNfL 浓度之间的相关性。此外，使用限制性立方样条（RCS）分析进一步探讨两者之间的非线性关系。
在调整了潜在的混杂因素后，与所有参与者相比，饮食中视黄醇摄入量增加 10%，sNfL 水平增加 3.47%（95%CI：0.54%，6.49%）。这种关系在特定亚组中更为明显，包括 60 岁以下、非肥胖、肾小球滤过率（eGFR）受损和非糖尿病患者。在亚组分析中，在 60 岁以下的人群中（百分比变化：3.80%；95%CI：0.43%，7.28%），非肥胖参与者（百分比变化：6.28%；95%CI：2.66%，10.02%）、eGFR 受损的参与者（百分比变化：6.90%；95%CI：1.44%，12.65%）和非糖尿病患者（百分比变化：4.17%；95%CI：1.08%，7.36%）中发现了变化。RCS 分析显示，饮食中视黄醇摄入与 sNfL 水平之间存在线性关系。此外，根据分段线性分析，在拐点之后，两者之间的正相关关系更为显著。
本研究揭示了饮食中视黄醇与 sNfL 水平之间呈 J 形关系，表明当饮食中视黄醇的摄入量超过特定阈值时，可能会发生轴突损伤。这些发现需要在未来的前瞻性研究中进一步证实，以确定可能引发轴突损伤的确切摄入水平。
Zotero 插件