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立体定向体部放射治疗复发性和寡转移性头颈部肿瘤

Stereotactic Body Radiotherapy in Recurrent and Oligometastatic Head and Neck Tumours.

作者信息

Tham Jodie L M, Ng Sweet Ping, Khor Richard, Wada Morikatsu, Gan Hui, Thai Alesha A, Corry June, Bahig Houda, Mäkitie Antti A, Nuyts Sandra, De Bree Remco, Strojan Primož, Ng Wai Tong, Eisbruch Avraham, Chow James C H, Ferlito Alfio

机构信息

Department of Radiation Oncology, Olivia Newton-John Cancer and Wellness Centre, Austin Health, Melbourne 3084, Australia.

Department of Medical Oncology, Olivia Newton-John Cancer and Wellness Centre, Austin Health, Melbourne 3084, Australia.

出版信息

J Clin Med. 2024 May 21;13(11):3020. doi: 10.3390/jcm13113020.

Abstract

The treatment of head and neck cancers (HNCs) encompasses a complex paradigm involving a combination of surgery, radiotherapy, and systemic treatment. Locoregional recurrence is a common cause of treatment failure, and few patients are suitable for salvage surgery. Reirradiation with conventional radiation techniques is challenging due to normal tissue tolerance limits and the risk of significant toxicities. Stereotactic body radiotherapy (SBRT) has emerged as a highly conformal modality that offers the potential for cure while limiting the dose to surrounding tissue. There is also growing research that shows that those with oligometastatic disease can benefit from curative intent local ablative therapies such as SBRT. This review will look at published evidence regarding the use of SBRT in locoregional recurrent and oligometastatic HNCs.

摘要

头颈部癌症(HNCs)的治疗是一个复杂的模式,涉及手术、放疗和全身治疗的联合应用。局部区域复发是治疗失败的常见原因,很少有患者适合挽救性手术。由于正常组织耐受限度以及严重毒性风险,采用传统放疗技术进行再程放疗具有挑战性。立体定向体部放疗(SBRT)已成为一种高度适形的治疗方式,在治愈疾病的同时可限制对周围组织的剂量。越来越多的研究表明,寡转移疾病患者可从SBRT等根治性局部消融治疗中获益。本综述将探讨关于SBRT在局部区域复发和寡转移HNCs中应用的已发表证据。

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