School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
Molecules. 2024 Jun 1;29(11):2606. doi: 10.3390/molecules29112606.
Biosurfactants derived from microorganisms have attracted widespread attention in scientific research due to their unique surface activity, low toxicity, biodegradability, antibacterial properties, and stability under extreme conditions. Biosurfactants are widely used in many fields, such as medicine, agriculture, and environmental protection. Therefore, this review aims to comprehensively review and analyze the various applications of biosurfactants in the medical field. The central roles of biosurfactants in crucial medical areas are explored, like drug delivery, induction of tumor cell differentiation or death, treating bacterial and viral effects, healing wounds, and immune regulation. Moreover, a new outlook is introduced on optimizing the capabilities of biosurfactants through modification and gene recombination for better use in medicine. The current research challenges and future research directions are described, aiming to provide valuable insights for continuous study of biosurfactants in medicine.
生物表面活性剂来源于微生物,由于其独特的表面活性、低毒性、可生物降解性、抗菌性能以及在极端条件下的稳定性,在科学研究中受到广泛关注。生物表面活性剂广泛应用于许多领域,如医学、农业和环境保护。因此,本综述旨在全面回顾和分析生物表面活性剂在医学领域的各种应用。探讨了生物表面活性剂在药物输送、诱导肿瘤细胞分化或死亡、治疗细菌和病毒作用、伤口愈合和免疫调节等关键医学领域的核心作用。此外,还通过修饰和基因重组引入了一种优化生物表面活性剂性能的新观点,以更好地用于医学。描述了当前的研究挑战和未来的研究方向,旨在为生物表面活性剂在医学中的不断研究提供有价值的见解。