血清 YKL-40 和血清 Krebs von den Lungen-6 作为类风湿关节炎相关间质性肺病的潜在预测生物标志物。
Serum YKL-40 and Serum Krebs von den Lungen-6 as Potential Predictive Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease.
机构信息
Department of Rheumatology and Immunology, Beijing Shunyi District Hospital, Shunyi Teaching Hospital of Capital Medical University, Beijing, China.
出版信息
Immunol Invest. 2024 Aug;53(6):989-1000. doi: 10.1080/08820139.2024.2366966. Epub 2024 Jun 20.
BACKGROUND
Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis (RA) and is associated with a poor prognosis. However, the role of blood biomarkers in RA-associated interstitial lung disease (RA-ILD) is ill-defined. We aim to evaluate the role of YKL-40 and Krebs von den Lungen-6 (KL-6) in the diagnosis and severity evaluation of RA-ILD.
METHODS
45 RA-non-ILD patients and 38 RA-ILD patients were included. The clinical data and the levels of YKL-40 and KL-6 were measured and collected for all patients. The risk factors for RA-ILD were analyzed and their correlation with relevant indicators and predictive value for RA-ILD was explored.
RESULTS
The levels of YKL-40 and KL-6 in RA-ILD patients were higher than RA-non-ILD patients ( < .001). Both YKL-40 and KL-6 were correlated with the incidence of RA-ILD. The predictive power of combined KL-6 and YKL-40 for the presence of ILD was 0.789, with a sensitivity and specificity at 73.7% and 73.3%, respectively. In RA-ILD patients, both YKL-40 and KL-6 were positively correlated with the Scleroderma Lung Study (SLS) I score and negatively correlated with pulmonary function.
CONCLUSIONS
KL-6 and YKL-40 might be a useful biomarker in the diagnosis and severity evaluation of RA-ILD.
背景
间质性肺疾病（ILD）是类风湿关节炎（RA）的一种常见肺部表现，与预后不良相关。然而，血液生物标志物在 RA 相关间质性肺疾病（RA-ILD）中的作用尚未明确。我们旨在评估 YKL-40 和 Krebs von den Lungen-6（KL-6）在 RA-ILD 的诊断和严重程度评估中的作用。
方法
纳入 45 例 RA-ILD 患者和 38 例 RA-非ILD 患者。测量并收集所有患者的临床数据和 YKL-40、KL-6 水平。分析 RA-ILD 的危险因素，并探讨其与相关指标的相关性及其对 RA-ILD 的预测价值。
结果
RA-ILD 患者的 YKL-40 和 KL-6 水平均高于 RA-非ILD 患者（<0.001）。YKL-40 和 KL-6 均与 RA-ILD 的发生相关。KL-6 和 YKL-40 联合对 ILD 存在的预测能力为 0.789，敏感性和特异性分别为 73.7%和 73.3%。在 RA-ILD 患者中，YKL-40 和 KL-6 均与硬皮病肺研究（SLS）I 评分呈正相关，与肺功能呈负相关。
结论
KL-6 和 YKL-40 可能是 RA-ILD 诊断和严重程度评估的有用生物标志物。
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