癌症幸存者的数字戒烟干预：一项随机对照试验中参与度和结果的预测因素及调节因素分析

Digital Smoking Cessation Intervention for Cancer Survivors: Analysis of Predictors and Moderators of Engagement and Outcome Alongside a Randomized Controlled Trial.

作者信息

Andree Rosa, Mujcic Ajla, den Hollander Wouter, van Laar Margriet, Boon Brigitte, Engels Rutger, Blankers Matthijs

机构信息

Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, Netherlands.

PsyQ, Parnassia Groep, The Hague, Netherlands.

出版信息

JMIR Cancer. 2024 Jun 20;10:e46303. doi: 10.2196/46303.

DOI:10.2196/46303

PMID:38901028

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11229662/

Abstract

BACKGROUND

Recent studies have shown positive, though small, clinical effects of digital smoking cessation (SC) interventions for cancer survivors. However, research on associations among participant characteristics, intervention engagement, and outcomes is limited.

OBJECTIVE

This study aimed to explore the predictors and moderators of engagement and outcome of MyCourse-Quit Smoking (in Dutch: "MijnKoers-Stoppen met Roken"), a digital minimally guided intervention for cancer survivors.

METHODS

A secondary analysis of data from the randomized controlled trial was performed. The number of cigarettes smoked in the past 7 days at 6-month follow-up was the primary outcome measure. We analyzed interactions among participant characteristics (11 variables), intervention engagement (3 variables), and outcome using robust linear (mixed) modeling.

RESULTS

In total, 165 participants were included in this study. Female participants accessed the intervention less often than male participants (B=-11.12; P=.004). A higher Alcohol Use Disorders Identification Test score at baseline was associated with a significantly higher number of logins (B=1.10; P<.001) and diary registrations (B=1.29; P<.001). A higher Fagerström Test for Nicotine Dependence score at baseline in the intervention group was associated with a significantly larger reduction in tobacco use after 6 months (B=-9.86; P=.002). No other associations and no moderating effects were found.

CONCLUSIONS

Overall, a limited number of associations was found between participant characteristics, engagement, and outcome, except for gender, problematic alcohol use, and nicotine dependence. Future studies are needed to shed light on how this knowledge can be used to improve the effects of digital SC programs for cancer survivors.

TRIAL REGISTRATION

Netherlands Trial register NTR6011/NL5434; https://onderzoekmetmensen.nl/nl/trial/22832.

摘要

背景

近期研究表明，数字戒烟干预措施对癌症幸存者有积极的临床效果，尽管效果较小。然而，关于参与者特征、干预参与度和结果之间关联的研究有限。

目的

本研究旨在探索“我的课程 - 戒烟”（荷兰语：“MijnKoers - Stoppen met Roken”）这一针对癌症幸存者的数字低指导干预措施的参与度和结果的预测因素及调节因素。

方法

对随机对照试验的数据进行二次分析。6个月随访时过去7天的吸烟量是主要结局指标。我们使用稳健线性（混合）模型分析参与者特征（11个变量）、干预参与度（3个变量）和结果之间的相互作用。

结果

本研究共纳入165名参与者。女性参与者使用该干预措施的频率低于男性参与者（B = -11.12；P = 0.004）。基线时酒精使用障碍识别测试得分较高与登录次数显著增加（B = 1.10；P < 0.001）和日记记录次数显著增加（B = 1.29；P < 0.001）相关。干预组基线时尼古丁依赖的Fagerström测试得分较高与6个月后烟草使用量显著减少相关（B = -9.86；P = 0.002）。未发现其他关联和调节作用。