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术后急性肾损伤的预测模型:大数据提高质量还是皇帝的新衣?

Predictive modelling for postoperative acute kidney injury: big data enhancing quality or the Emperor's new clothes?

机构信息

Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Anaesthesia, Monash University, Melbourne, VIC, Australia.

出版信息

Br J Anaesth. 2024 Sep;133(3):476-478. doi: 10.1016/j.bja.2024.05.013. Epub 2024 Jun 19.

Abstract

The increased availability of large clinical datasets together with increasingly sophisticated computing power has facilitated development of numerous risk prediction models for various adverse perioperative outcomes, including acute kidney injury (AKI). The rationale for developing such models is straightforward. However, despite numerous purported benefits, the uptake of preoperative prediction models into clinical practice has been limited. Barriers to implementation of predictive models, including limitations in their discrimination and accuracy, as well as their ability to meaningfully impact clinical practice and patient outcomes, are increasingly recognised. Some of the purported benefits of predictive modelling, particularly when applied to postoperative AKI, might not fare well under detailed scrutiny. Future research should address existing limitations and seek to demonstrate both benefit to patients and value to healthcare systems from implementation of these models in clinical practice.

摘要

大型临床数据集的可用性增加以及计算能力的日益提高,促进了许多用于各种围手术期不良结局(包括急性肾损伤[AKI])风险预测模型的开发。开发此类模型的原理很简单。然而,尽管有许多据称的益处,但术前预测模型在临床实践中的应用仍然有限。预测模型实施的障碍,包括其区分能力和准确性的限制,以及其对临床实践和患者结局产生有意义影响的能力,正日益受到认识。一些预测建模的所谓益处,特别是当应用于术后 AKI 时,在详细审查下可能并不过关。未来的研究应该解决现有局限性,并努力从这些模型在临床实践中的应用中为患者带来的益处和为医疗保健系统带来的价值两个方面来证明其合理性。

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