MetaCompass：宏基因组的参考引导组装

MetaCompass: Reference-guided Assembly of Metagenomes.

作者信息

Luan Tu, Cepeda Victoria, Liu Bo, Bowen Zac, Ayyangar Ujjwal, Almeida Mathieu, Hill Christopher M, Koren Sergey, Treangen Todd J, Porter Adam, Pop Mihai

机构信息

Department of Computer Science, University of Maryland, College Park, Maryland, USA.

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, Maryland, USA.

出版信息

ArXiv. 2024 Mar 3:arXiv:2403.01578v1.

PMID:38903742

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11188144/

Abstract

Metagenomic studies have primarily relied on assembly for reconstructing genes and genomes from microbial mixtures. While reference-guided approaches have been employed in the assembly of single organisms, they have not been used in a metagenomic context. Here we describe the first effective approach for reference-guided metagenomic assembly that can complement and improve upon metagenomic assembly methods for certain organisms. Such approaches will be increasingly useful as more genomes are sequenced and made publicly available.

摘要

宏基因组学研究主要依靠组装来从微生物混合物中重建基因和基因组。虽然参考引导方法已用于单个生物体的组装，但尚未在宏基因组学背景下使用。在这里，我们描述了第一种有效的参考引导宏基因组组装方法，该方法可以补充和改进某些生物体的宏基因组组装方法。随着越来越多的基因组被测序并公开可用，这种方法将变得越来越有用。