BAllC 和 BAllCools：单细胞 DNA 甲基化数据的高效格式化和操作。
BAllC and BAllCools: efficient formatting and operating for single-cell DNA methylation data.
机构信息
Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, United States.
Department of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO 63110, United States.
出版信息
Bioinformatics. 2024 Jul 1;40(7). doi: 10.1093/bioinformatics/btae404.
MOTIVATION
With single-cell DNA methylation studies yielding vast datasets, existing data formats struggle with the unique challenges of storage and efficient operations, highlighting a need for improved solutions.
RESULTS
BAllC (Binary All Cytosines) emerges as a tailored format for methylation data, addressing these challenges. BAllCools, its complementary software toolkit, enhances parsing, indexing, and querying capabilities, promising superior operational speeds and reduced storage needs.
AVAILABILITY AND IMPLEMENTATION
动机
单细胞 DNA 甲基化研究产生了大量数据集，现有数据格式在存储和高效操作方面面临独特的挑战，这凸显了对改进解决方案的需求。
结果
BAllC（二进制全胞嘧啶）作为一种针对甲基化数据的定制格式出现，解决了这些挑战。BAllCools 是其配套的软件工具包，增强了解析、索引和查询功能，有望实现更高的操作速度和更低的存储需求。
可用性和实现
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