大肠杆菌乳糖通透酶中苏氨酸266突变为异亮氨酸会减少乳糖的转运并增加麦芽糖的转运。
A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose.
作者信息
Markgraf M, Bocklage H, Müller-Hill B
出版信息
Mol Gen Genet. 1985;198(3):473-5. doi: 10.1007/BF00332941.
PMID:3892229
Abstract
The DNA sequence of several functionally interesting lac permease mutants of Escherichia coli has been determined. The phenotypes of the mutant permeases were described by Mieschendahl et al. (1981). The following exchanges are noteworthy: tyr to asp in codon 26 in Y-K MUB 7; thr to ile in codon 266 in Y-K AJ 33; gly to asp in codon 262 in Y-D 3 and in Y-D 4.
摘要
已确定了几种具有功能意义的大肠杆菌乳糖通透酶突变体的DNA序列。Mieschendahl等人（1981年）描述了这些突变通透酶的表型。以下交换值得注意：Y-K MUB 7中第26密码子处酪氨酸突变为天冬氨酸；Y-K AJ 33中第266密码子处苏氨酸突变为异亮氨酸；Y-D 3和Y-D 4中第262密码子处甘氨酸突变为天冬氨酸。
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