[沙眼衣原体感染的HeLa 229细胞中超氧化物歧化酶和过氧化氢酶活性]
[Superoxide dismutase and catalase activity in HeLa 229 cells infected with Chlamydia trachomatis].
作者信息
Weber P, Sinaceur J, Ribière C, Le Pennec M P, Ghnassia J C, Nordmann R
出版信息
Pathol Biol (Paris). 1985 Mar;33(3):179-82.
Cytosolic superoxide dismutase (SOD) activity was found to increase with time during HeLa cell culture, this increase being due exclusively to Mn-SOD. Infection of the cells by Chlamydia trachomatis resulted in a further enhancement of this Mn-SOD activity, whereas cytosolic catalase activity was decreased in these infected cells. Superoxide (O-2.) being able to induce Mn-SOD and to inhibit catalase, these data suggest that Chlamydia trachomatis infection could be responsible for an increase in O-2. production by the infected HeLa cells.
在HeLa细胞培养过程中，发现胞质超氧化物歧化酶（SOD）活性随时间增加，这种增加完全归因于锰超氧化物歧化酶（Mn-SOD）。沙眼衣原体感染细胞导致这种Mn-SOD活性进一步增强，而这些受感染细胞中的胞质过氧化氢酶活性降低。超氧阴离子（O₂⁻）能够诱导Mn-SOD并抑制过氧化氢酶，这些数据表明沙眼衣原体感染可能导致受感染的HeLa细胞中O₂⁻产生增加。
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