Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Department of Medicine, Government Kilpauk Medical College, Chennai 600010, Tamilnadu, India.
Molecules. 2024 Jun 17;29(12):2873. doi: 10.3390/molecules29122873.
Atherosclerosis continues to be a leading cause of morbidity and mortality globally. The precise evaluation of the extent of an atherosclerotic plaque is essential for forecasting its likelihood of causing health concerns and tracking treatment outcomes. When compared to conventional methods used, nanoparticles offer clear benefits and excellent development opportunities for the detection and characterisation of susceptible atherosclerotic plaques. In this review, we analyse the recent advancements of nanoparticles as theranostics in the management of atherosclerosis, with an emphasis on applications in drug delivery. Furthermore, the main issues that must be resolved in order to advance clinical utility and future developments of NP research are discussed. It is anticipated that medical NPs will develop into complex and advanced next-generation nanobotics that can carry out a variety of functions in the bloodstream.
动脉粥样硬化仍然是全球发病率和死亡率的主要原因。精确评估动脉粥样硬化斑块的程度对于预测其引起健康问题的可能性和跟踪治疗效果至关重要。与传统方法相比,纳米颗粒在检测和表征易损性动脉粥样硬化斑块方面具有明显的优势和极好的发展机遇。在这篇综述中,我们分析了纳米颗粒作为动脉粥样硬化治疗的诊断和治疗一体化的最新进展,重点讨论了在药物输送方面的应用。此外,还讨论了为推进 NP 研究的临床应用和未来发展而必须解决的主要问题。预计医用 NPs 将发展成为能够在血液中执行多种功能的复杂而先进的下一代纳米机器人。