阿片类镇痛药在骨关节炎治疗中的不良反应：一项2000 - 2022年的全球荟萃分析

Adverse Effects of Opioid Analgesics in Osteoarthritis Treatment: A Global Meta-Analysis, 2000-2022.

作者信息

Jiang Heng, Xing Xing, Zhu He, Dong Tuo

机构信息

School of Public Health, Harbin Medical University, Harbin City, Heilongjiang Province, China.

School of Public Health, Peking University, Beijing, China.

出版信息

China CDC Wkly. 2024 Jun 21;6(25):589-596. doi: 10.46234/ccdcw2024.115.

DOI:10.46234/ccdcw2024.115

PMID:38933042

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11196880/

Abstract

Osteoarthritis (OA) treatment commonly depends on nonsteroidal anti-inflammatory drugs and opioid medications. Nevertheless, the clinical use of opioids is controversial due to their adverse effects and addiction potential. This study, drawing on 24 randomized controlled trials (RCTs) with a total of 9,586 patients, thoroughly explored the various side effects associated with opioid use in OA treatment. The results provide additional insight into the non-addictive risks of opioids and may assist clinicians in their judicious use, potentially fostering the advancement of safer treatment options. By reducing the risks of misuse and addiction, public health and safety can be enhanced.

摘要

骨关节炎（OA）的治疗通常依赖于非甾体抗炎药和阿片类药物。然而，由于阿片类药物的副作用和成瘾潜力，其临床应用存在争议。本研究基于24项随机对照试验（RCT），共纳入9586例患者，全面探讨了OA治疗中使用阿片类药物相关的各种副作用。研究结果为阿片类药物的非成瘾性风险提供了更多见解，可能有助于临床医生明智地使用这些药物，从而推动更安全治疗方案的发展。通过降低滥用和成瘾风险，可以提高公众健康和安全水平。