肌萎缩侧索硬化症和额颞叶变性中脑脊液和血液神经丝轻链水平：一项荟萃分析。
Cerebrospinal fluid and blood neurofilament light chain levels in amyotrophic lateral sclerosis and frontotemporal degeneration: A meta-analysis.
机构信息
Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Department of Pathophysiology and Transplantation, Dino Ferrari Center, Università degli Studi di Milano, Milan, Italy.
出版信息
Eur J Neurol. 2024 Sep;31(9):e16371. doi: 10.1111/ene.16371. Epub 2024 Jun 27.
BACKGROUND AND PURPOSE
Neurofilament light chain (NFL) has been shown to be increased in amyotrophic lateral sclerosis (ALS) and, to a lesser extent, in frontotemporal dementia (FTD). A meta-analysis of NFL in ALS and FTD was performed.
METHODS
Available studies comparing cerebrospinal fluid and blood NFL levels in ALS versus neurologically healthy controls (NHCs), other neurological diseases (ONDs) and ALS mimics, as well as in FTD and related entities (behavioural variant of FTD and frontotemporal lobar degeneration syndromes) versus NHCs, ONDs and other dementias were evaluated.
RESULTS
In ALS, both cerebrospinal fluid and blood levels of NFL were higher compared to other categories. In FTD, behavioural variant of FTD and frontotemporal lobar degeneration syndromes, NFL levels were consistently higher compared to NHCs; however, several comparisons with ONDs and other dementias did not demonstrate significant differences.
DISCUSSION
Amyotrophic lateral sclerosis is characterized by higher NFL levels compared to most other conditions. In contrast, NFL is not as good at discriminating FTD from other dementias.
背景与目的
神经丝轻链（NFL）在肌萎缩侧索硬化症（ALS）中增加，在额颞叶痴呆（FTD）中则略有增加。对 ALS 和 FTD 中的 NFL 进行了荟萃分析。
方法
评估了比较 ALS 患者与神经健康对照组（NHC）、其他神经疾病（OND）和 ALS 模拟物的脑脊液和血液 NFL 水平，以及 FTD 和相关实体（行为变异型 FTD 和额颞叶变性综合征）与 NHC、OND 和其他痴呆症的可用研究。
结果
在 ALS 中，脑脊液和血液中的 NFL 水平均高于其他类别。在 FTD 中，行为变异型 FTD 和额颞叶变性综合征的 NFL 水平始终高于 NHC；然而，与 OND 和其他痴呆症的一些比较并未显示出显著差异。
讨论
与大多数其他疾病相比，肌萎缩侧索硬化症的 NFL 水平更高。相比之下，NFL 在区分 FTD 与其他痴呆症方面效果不佳。
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