向家兔下丘脑腹内侧核微量注射胰岛素对肝脏切片中乙酸代谢的影响。
Influence of microinjection of insulin into ventromedial hypothalamus on acetate metabolism in liver slices of rabbit.
作者信息
Seto K, Saito H, Kaba H, Tanaka J, Iguchi A, Sakamoto N, Kawakami M
出版信息
Exp Clin Endocrinol. 1985 Apr;85(2):253-6. doi: 10.1055/s-0029-1210446.
Insulin was injected directly into the ventromedial hypothalamic nuclei (VMH) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 50 microU insulin into the VMH of intact rabbits decreased the rates of 14C transfer from 14C-1-acetate into glucose and cholesterol ester in liver slices. But after insulin injection into the parietal cortex of intact rabbits and into the VMH of rabbits with VMH lesions, hepatic acetate metabolism did not differ from that of the control rabbits, which received saline injection into the same brain regions. These observations support the hypothesis that the VMH are parts of an insulin-sensitive brain regulator system in the hepatic acetate metabolism.
将胰岛素直接注入家兔腹内侧下丘脑核（VMH），并研究肝脏乙酸代谢的变化。向完整家兔的VMH注射50微单位胰岛素，可降低肝切片中14C从14C-1-乙酸盐向葡萄糖和胆固醇酯的转移速率。但是，向完整家兔的顶叶皮质以及VMH损伤的家兔的VMH注射胰岛素后，肝脏乙酸代谢与对照家兔（在相同脑区注射生理盐水）并无差异。这些观察结果支持了以下假说：VMH是肝脏乙酸代谢中胰岛素敏感脑调节系统的组成部分。
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