Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.
Neuroscience Graduate Group, University of California, Davis, CA, USA.
Neuropsychopharmacology. 2024 Nov;50(1):269-273. doi: 10.1038/s41386-024-01903-5. Epub 2024 Jun 28.
Psychiatric research encompasses diverse methodologies to understand the complex interplay between neurochemistry and behavior in mental health disorders. Despite significant advancements in pharmacological interventions, there remains a critical gap in understanding the precise functional changes underlying psychiatric conditions and the mechanisms of action of therapeutic agents. Genetically encoded sensors have emerged as powerful tools to address these challenges by enabling real-time monitoring of neurochemical dynamics in specific neuronal populations. This prospective explores the utility of neurotransmitter binding genetically encoded sensors in uncovering the nature of neuronal dysregulation underpinning mental illness, assessing the impact of pharmaceutical interventions, and facilitating the discovery of novel treatments.
精神疾病研究涵盖了多种方法，旨在理解精神健康障碍中神经化学和行为之间的复杂相互作用。尽管在药物干预方面取得了重大进展，但在理解精神疾病背后的精确功能变化和治疗药物的作用机制方面仍存在关键差距。基因编码传感器的出现为解决这些挑战提供了有力的工具，可实现特定神经元群体中神经化学动力学的实时监测。本前瞻性研究探讨了神经递质结合基因编码传感器在揭示精神疾病中神经元失调的本质、评估药物干预的影响以及促进新疗法发现方面的应用。
