甘油三酯-葡萄糖指数在识别斯里兰卡北部成年人代谢综合征中的判别能力。

The discriminative ability of the triglyceride-glucose index to identify metabolic syndrome among adults of the northern Sri Lankan population.

机构信息

Department of Biochemistry, Faculty of Medicine, University of Jaffna, Jaffna, Sri Lanka.

Department of Medicine, Faculty of Medicine, University of Jaffna, Jaffna, Sri Lanka.

出版信息

BMC Endocr Disord. 2024 Jul 1;24(1):101. doi: 10.1186/s12902-024-01632-2.

DOI:10.1186/s12902-024-01632-2

PMID:38951832

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11218160/

Abstract

BACKGROUND

The triglyceride-glucose index (TyG index) is a simple surrogate marker for Insulin Resistance (IR). However, the relationship between the TyG index and Metabolic Syndrome (MetS) remains unknown in the Northern Sri Lankan population.

METHODS

This was a descriptive, cross-sectional study of adults aged between 18 and 65 years living in Jaffna, Sri Lanka. This study aimed to verify the discriminative ability of the TyG index to identify MetS using the International Diabetes Federation (IDF-2006) criteria and to determine the gender-specific TyG index cut-off values for better prediction of MetS in Northern Sri Lankan adults. TyG index was calculated as Ln[Triglycerides (TG) (mg/dl) × Fasting plasma glucose (FPG) (mg/dl)/2].

RESULTS

A total of 540 individuals were included in this study, with a mean age of 42.18 (± 13.89) years for males and 43.80 (± 12.56) years for females. The mean value of the TyG index in the total study population was 8.54 (± 0.53). Individuals in the higher quartiles of the TyG index had a significantly increased risk of MetS compared with those in the lowest quartile (p < 0.01). TyG index showed a stronger association with MetS than the FPG and all the conventional lipid components and the unadjusted odds ratio was 5.47. The area under the curve (AUC) of ROC revealed values of 0.914 (95% confidence interval (CI): 0.884, 0.944) for females, 0.881 (95% CI: 0.830, 0.932) for males and 0.897 (95% CI: 0.870, 0.924) for the total study population. TyG index had a stronger discriminative ability to identify MetS as per IDF criteria in the study population with a cut-off value of 8.60. The mean level of the TyG index significantly increased with the increasing number of MetS components.

CONCLUSIONS

The mean value of the TyG index increased as the number of MetS components in the study population increased. Individuals with a higher TyG index had a significantly increased risk of having MetS compared with the lowest quartile of the TyG index. TyG index had a good discriminative ability to diagnose MetS as per IDF criteria among the northern Sri Lankan population.

摘要

背景

三酰甘油-葡萄糖指数（TyG 指数）是胰岛素抵抗（IR）的简单替代标志物。然而，在北斯里兰卡人群中，TyG 指数与代谢综合征（MetS）之间的关系尚不清楚。

方法

这是一项在贾夫纳（斯里兰卡）居住的 18 至 65 岁成年人中进行的描述性、横断面研究。本研究旨在验证 TyG 指数根据国际糖尿病联合会（IDF-2006）标准识别代谢综合征的判别能力，并确定北斯里兰卡成年人更好地预测代谢综合征的性别特异性 TyG 指数切点值。TyG 指数的计算方法为 Ln[三酰甘油（TG）（mg/dl）×空腹血糖（FPG）（mg/dl）/2]。

结果

本研究共纳入 540 人，男性平均年龄为 42.18（±13.89）岁，女性平均年龄为 43.80（±12.56）岁。总研究人群中 TyG 指数的平均值为 8.54（±0.53）。与最低四分位组相比，TyG 指数较高四分位组的代谢综合征风险显著增加（p<0.01）。TyG 指数与代谢综合征的相关性强于 FPG 和所有常规血脂成分，未经调整的优势比为 5.47。ROC 曲线下面积（AUC）显示女性为 0.914（95%置信区间（CI）：0.884，0.944），男性为 0.881（95%CI：0.830，0.932），总研究人群为 0.897（95%CI：0.870，0.924）。在具有 8.60 切点值的研究人群中，TyG 指数对根据 IDF 标准识别代谢综合征具有更强的判别能力。TyG 指数的平均水平随着研究人群中代谢综合征成分数量的增加而增加。与 TyG 指数最低四分位组相比，TyG 指数较高的个体发生代谢综合征的风险显著增加。TyG 指数在北斯里兰卡人群中具有良好的判别能力，可根据 IDF 标准诊断代谢综合征。