多药耐药性对铜绿假单胞菌毒力和适应性的影响：微生物学和临床视角。
Impact of multidrug resistance on the virulence and fitness of Pseudomonas aeruginosa: a microbiological and clinical perspective.
机构信息
Infectious Diseases Service, Hospital del Mar, Infectious Pathology and Antimicrobials Research Group (IPAR), Hospital del Mar Research Institute, Universitat Autònoma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, Passeig Marítim 25-27, 08003, Barcelona, Spain.
Research Unit, University Hospital Son Espases-Health Research Institute of the Balearic Islands (IdISBa), Microbiology Department, University Hospital Son Espases, Crtra. Valldemossa 79, 07010, Palma, Spain.
出版信息
Infection. 2024 Aug;52(4):1235-1268. doi: 10.1007/s15010-024-02313-x. Epub 2024 Jul 2.
Abstract
Pseudomonas aeruginosa is one of the most common nosocomial pathogens and part of the top emergent species associated with antimicrobial resistance that has become one of the greatest threat to public health in the twenty-first century. This bacterium is provided with a wide set of virulence factors that contribute to pathogenesis in acute and chronic infections. This review aims to summarize the impact of multidrug resistance on the virulence and fitness of P. aeruginosa. Although it is generally assumed that acquisition of resistant determinants is associated with a fitness cost, several studies support that resistance mutations may not be associated with a decrease in virulence and/or that certain compensatory mutations may allow multidrug resistance strains to recover their initial fitness. We discuss the interplay between resistance profiles and virulence from a microbiological perspective but also the clinical consequences in outcomes and the economic impact.
摘要
铜绿假单胞菌是最常见的医院获得性病原体之一，也是与抗菌药物耐药性相关的顶级新兴物种之一，它已成为 21 世纪对公众健康的最大威胁之一。该细菌具有广泛的毒力因子，有助于急性和慢性感染的发病机制。本综述旨在总结多药耐药性对铜绿假单胞菌毒力和适应性的影响。尽管通常认为获得耐药决定因素与适应性成本相关，但有几项研究表明，耐药突变可能与毒力降低无关，或者某些补偿性突变可能使多药耐药菌株恢复其初始适应性。我们从微生物学的角度讨论了耐药谱和毒力之间的相互作用，但也讨论了临床结果和经济影响方面的后果。
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