人体心脏代谢。
Human cardiac metabolism.
机构信息
Cardiovascular Institute Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA, USA.
出版信息
Cell Metab. 2024 Jul 2;36(7):1456-1481. doi: 10.1016/j.cmet.2024.06.003.
Abstract
The heart is the most metabolically active organ in the human body, and cardiac metabolism has been studied for decades. However, the bulk of studies have focused on animal models. The objective of this review is to summarize specifically what is known about cardiac metabolism in humans. Techniques available to study human cardiac metabolism are first discussed, followed by a review of human cardiac metabolism in health and in heart failure. Mechanistic insights, where available, are reviewed, and the evidence for the contribution of metabolic insufficiency to heart failure, as well as past and current attempts at metabolism-based therapies, is also discussed.
摘要
心脏是人体中代谢最活跃的器官，几十年来，人们一直致力于研究心脏代谢。然而，大部分研究都集中在动物模型上。本综述的目的是专门总结关于人类心脏代谢的已知内容。本文首先讨论了用于研究人类心脏代谢的技术，然后综述了健康和心力衰竭状态下的人类心脏代谢。本文还回顾了心脏代谢机制方面的研究进展，以及代谢不足导致心力衰竭的证据，以及过去和当前基于代谢的治疗方法。
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