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透视引导下关节内注射类固醇治疗腰椎小关节病的功能结局:地塞米松与曲安奈德的回顾性对比研究

Functional Outcomes of Fluoroscopy-Guided Intra-articular Steroids in Lumbar Facet Arthropathy: A Retrospective Comparative Study of Dexamethasone Versus Triamcinolone Acetonide.

作者信息

Gandhi Gowtham, Ethiraj Prabhu, Ramachandraiah Manoj K, Kumaar Arun

机构信息

Department of Orthopaedics, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, IND.

出版信息

Cureus. 2024 Jun 2;16(6):e61551. doi: 10.7759/cureus.61551. eCollection 2024 Jun.

Abstract

Introduction  Mechanical low back pain frequently originates from the lumbar facet joint (LFJ). Axial low back discomfort can result from osteoarthritis in the LFJ. Depending on the severity of LFJ degeneration, the effect of intra-articular (IA) LFJ corticosteroid injection may vary. For LFJ discomfort, IA block with steroids and local anaesthetics has also been utilised, with varying degrees of success. The main objective of this study was to assess the efficacy of IA steroid injections dexamethasone vs. triamcinolone acetonide for the treatment of LFJ syndrome and to compare functional outcome in terms of Visual Analog Scale (VAS) score, Modified Oswestry Disability Index (MODI) score, and short-form McGill Pain Questionnaire between the two groups. Methodology Dexamethasone 8 mg or triamcinolone acetonide 40 mg was given intra-articularly to 27 patients comprising group A and 33 patients comprising group B, respectively (total 60 patients). Before intervention and at one, three, and six months, observation was conducted using the VAS score, short-form McGill pain questionnaire, and MODI score. Results There was a significant difference between both the groups after the procedure with pain alleviation and functional improvement, more in the group that received triamcinolone acetonide. A significant difference was observed in all three parameters that assessed pain with differences more pronounced at six months. Conclusion Pain reduction and clinical outcomes were better among the group that received triamcinolone acetonide. Injection of a steroid alone is associated with its own side effects. When a lumbar transforaminal epidural injection is used to treat radiculopathy in the lumbar area, particulate medication (triamcinolone) is more effective than non-particulate medication (dexamethasone) with no known drug-related complications.

摘要

引言 机械性下背痛常起源于腰椎小关节(LFJ)。腰椎小关节的骨关节炎可导致轴向性下背不适。根据腰椎小关节退变的严重程度,关节内(IA)注射皮质类固醇治疗腰椎小关节的效果可能有所不同。对于腰椎小关节不适,也采用了类固醇和局部麻醉剂的关节内阻滞,且取得了不同程度的成功。本研究的主要目的是评估关节内注射地塞米松与曲安奈德治疗腰椎小关节综合征的疗效,并比较两组在视觉模拟量表(VAS)评分、改良奥斯维斯特里功能障碍指数(MODI)评分和简短麦吉尔疼痛问卷方面的功能结局。方法 分别对A组27例患者和B组33例患者进行关节内注射8 mg地塞米松或40 mg曲安奈德(共60例患者)。在干预前以及干预后1个月、3个月和6个月,使用VAS评分、简短麦吉尔疼痛问卷和MODI评分进行观察。结果 两组在治疗后疼痛缓解和功能改善方面存在显著差异,接受曲安奈德治疗的组差异更明显。在评估疼痛的所有三个参数中均观察到显著差异,在6个月时差异更为显著。结论 接受曲安奈德治疗的组疼痛减轻和临床结局更好。单独注射类固醇会有其自身的副作用。当使用腰椎经椎间孔硬膜外注射治疗腰椎神经根病时,颗粒状药物(曲安奈德)比非颗粒状药物(地塞米松)更有效,且无已知的药物相关并发症。

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