Department of Paediatrics, University of Liege (ULg), CHU, 4000, Liege, Belgium; GIGA Neurosciences, Neuroendocrinology Unit, University of Liege (ULg), CHU, 4000, Liege, Belgium.
Laboratory of Clinical, Forensic and Environmental Toxicology, University of Liege (ULg), CHU, 4000, Liege, Belgium.
Int J Hyg Environ Health. 2024 Aug;261:114422. doi: 10.1016/j.ijheh.2024.114422. Epub 2024 Jul 8.
Strong experimental evidence exists that several endocrine disrupting chemicals (EDCs) have neurobehavioral toxicity. However, evidence of associations between prenatal exposure and child's cognitive development is inconsistent. Moreover, toxicants are generally analyzed one by one without considering aggregate effects. We examined here the impact of a prenatal exposure to a mixture of persistent organic pollutants (POPs) on intellectual abilities in preschool children, and compared their effects to those described in the literature.
Sixty-two children were included in a longitudinal cohort. Four organochlorine pesticides, four polychlorinated biphenyls (PCBs) and seven perfluorinated compounds (PFCs) were measured in cord blood. Intellectual abilities were assessed at 6 years of age using the Wechsler Preschool and Primary Scale of Intelligence 4th ed. (WPPSI-IV). We examined the associations between a mixture of POPs and cognitive performances using principal components approach (PCA) and weighted quantile sum (WQS) regression taking sex difference into account.
No negative correlation was found when analyses were performed on boys and girls together. In sex-stratified analyses, lower scores in full scale intelligence quotient (FSIQ) and fluid reasoning index (FRI) were observed in boys most exposed to a mixture of POPs. Increase of the WQS index was also associated with lower verbal comprehension index (VCI) scores in girls only. No other negative correlation was found using both WQS and PCA models.
Our study suggests deleterious associations between antenatal exposure to a mixture of POPs and sex-specific cognitive level, clarifying some trends described in the literature.
有大量实验证据表明，一些内分泌干扰化学物质（EDCs）具有神经行为毒性。然而，产前暴露与儿童认知发展之间的关联证据并不一致。此外，通常是逐个分析有毒物质，而不考虑其综合效应。我们在此研究了产前暴露于持久性有机污染物（POPs）混合物对学龄前儿童智力的影响，并将其影响与文献中描述的进行了比较。
62 名儿童被纳入一项纵向队列研究。在脐带血中测量了四种有机氯农药、四种多氯联苯（PCBs）和七种全氟化合物（PFCs）。在 6 岁时使用韦氏学前和小学智力量表第四版（WPPSI-IV）评估智力能力。我们采用主成分分析（PCA）和加权分位数和（WQS）回归方法，考虑性别差异，研究了 POPs 混合物与认知表现之间的关联。
当对男孩和女孩进行综合分析时，未发现任何负相关关系。在性别分层分析中，暴露于 POPs 混合物最多的男孩的全智商（FSIQ）和流体推理指数（FRI）得分较低。仅在女孩中，WQS 指数的增加与言语理解指数（VCI）得分降低有关。使用 WQS 和 PCA 模型均未发现其他负相关关系。
我们的研究表明，产前暴露于 POPs 混合物与性别特异性认知水平之间存在有害关联，阐明了文献中描述的一些趋势。
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