Meng Xiang-Da, Li Ting-Ting, Deng Li-Min
Department of Otolaryngology, The First Affiliated Hospital of Qiqihar Medical University, Qiqihar 161041, Heilongjiang Province, China.
Department of Otolaryngology Head and Neck Surgery, Harbin Medical University Affiliated Fourth Hospital University, Harbin 150001, Heilongjiang Province, China.
World J Clin Cases. 2024 Jun 26;12(18):3321-3331. doi: 10.12998/wjcc.v12.i18.3321.
Sudden sensorineural hearing loss (SSNHL), characterized by a rapid and unexplained loss of hearing, particularly at moderate to high frequencies, presents a significant clinical challenge. The therapeutic use of methylprednisolone sodium succinate (MPSS) via different administration routes, in combination with conventional medications, remains a topic of interest.
To compare the therapeutic efficacy of MPSS administered via different routes in combination with conventional drugs for the treatment of mid- to high-frequency SSNHL.
The medical records of 109 patients with mid- to high-frequency SSNHL were analyzed. The patients were divided into three groups based on the route of administration: Group A [intratympanic (IT) injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection], Group B (intravenous injection of MPSS combined with mecobalamin and Ginkgo biloba leaf extract injection), and Group C (single IT injection of MPSS). The intervention effects were compared and analyzed.
The posttreatment auditory thresholds in Group A (21.23 ± 3 .34) were significantly lower than those in Groups B (28.52 ± 3.36) and C (30.23 ± 4.21; < 0.05). Group A also exhibited a significantly greater speech recognition rate (92.23 ± 5.34) than Groups B and C. The disappearance time of tinnitus, time to hearing recovery, and disappearance time of vertigo in Group A were significantly shorter than those in Groups B and C ( < 0.05). The total effective rate in Group A (97.56%) was significantly greater than that in Groups B and C (77.14% and 78.79%, = 7.898, = 0.019). Moreover, the incidence of adverse reactions in Groups A and C was significantly lower than that in Group B (4.88%, 3.03% 2.57%, = 11.443, = 0.003), and the recurrence rate in Group A was significantly lower than that in Groups B and C (2.44% 20.00% 21.21%, = 7.120, = 0.028).
IT injection of MPSS combined with conventional treatment demonstrates superior efficacy and safety compared to systemic administration via intravenous infusion and a single IT injection of MPSS. This approach effectively improves patients' hearing and reduces the risk of disease recurrence.
突发性感音神经性听力损失（SSNHL），其特征为听力迅速且原因不明地丧失，尤其是在中高频，这是一个重大的临床挑战。通过不同给药途径使用甲泼尼龙琥珀酸钠（MPSS）并结合传统药物进行治疗，仍然是一个受关注的话题。
比较不同途径给药的MPSS联合传统药物治疗中高频SSNHL的疗效。
分析109例中高频SSNHL患者的病历。根据给药途径将患者分为三组：A组[鼓室内（IT）注射MPSS联合甲钴胺和银杏叶提取物注射液]，B组（静脉注射MPSS联合甲钴胺和银杏叶提取物注射液），C组（单次IT注射MPSS）。比较并分析干预效果。
A组治疗后的听阈（21.23±3.34）显著低于B组（28.52±3.36）和C组（30.23±4.21；P<0.05）。A组的言语识别率（92.23±5.34）也显著高于B组和C组。A组耳鸣消失时间、听力恢复时间和眩晕消失时间均显著短于B组和C组（P<0.05）。A组的总有效率（97.56%）显著高于B组和C组（77.14%和78.79%，χ²=7.898，P=0.019）。此外，A组和C组的不良反应发生率显著低于B组（4.88%、3.03%对2.57%，χ²=11.443，P=0.003），A组的复发率显著低于B组和C组（2.44%对20.00%、21.21%，χ²=7.120，P=0.028）。
与静脉输注全身给药和单次IT注射MPSS相比，IT注射MPSS联合传统治疗显示出更好的疗效和安全性。这种方法有效地改善了患者的听力并降低了疾病复发的风险
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