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肠道微生物群:高血压的一种潜在新调节因子。

Gut microbiota: a potential new regulator of hypertension.

作者信息

Ge Yanmin, Wang Jiaxin, Wu Lincong, Wu Junduo

机构信息

Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, China.

Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Front Cardiovasc Med. 2024 Jun 27;11:1333005. doi: 10.3389/fcvm.2024.1333005. eCollection 2024.

Abstract

Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases and has become a global public health concern. Although hypertension results from a combination of factors, the specific mechanism is still unclear. However, increasing evidence suggests that gut microbiota is closely associated with the development of hypertension. We provide a summary of the composition and physiological role of gut microbiota. We then delve into the mechanism of gut microbiota and its metabolites involved in the occurrence and development of hypertension. Finally, we review various regimens for better-controlling hypertension from the diet, exercise, drugs, antibiotics, probiotics, and fecal transplantation perspectives.

摘要

高血压是心脑血管疾病的重要危险因素,已成为全球公共卫生问题。尽管高血压是多种因素共同作用的结果,但其具体机制仍不清楚。然而,越来越多的证据表明,肠道微生物群与高血压的发生密切相关。我们总结了肠道微生物群的组成和生理作用。然后深入探讨肠道微生物群及其代谢产物参与高血压发生发展的机制。最后,我们从饮食、运动、药物、抗生素、益生菌和粪便移植等角度综述了更好控制高血压的各种方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772a/11236727/fbfd2643d8a5/fcvm-11-1333005-g001.jpg

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