Zaccardelli Alessandra, Lucas Fabienne M, LaCasce Ann S, Chandraker Anil K, Azzi Jamil R, Talbot Simon G
Department of Medical Education, Tufts University School of Medicine, Boston, MA, United States.
Department of Pathology, Brigham and Women's Hospital, Boston, MA, United States.
Front Transplant. 2024 Mar 14;3:1339898. doi: 10.3389/frtra.2024.1339898. eCollection 2024.
Vascularized composite allotransplantation (VCA) is an emerging field in transplant surgery. Despite overall positive outcomes, VCA confers risk for multiple complications related to the procedure and subsequent immunosuppression. Post-transplant lymphoproliferative disorder (PTLD) is a heterogeneous group of lymphoproliferative disorders occurring after solid organ and hematopoietic stem cell transplant. A patient with PTLD after bilateral upper extremity transplantation is presented as well as a review of all known cases of PTLD after VCA, with a focus on the unique epidemiology, presentation, and treatment in this population.
血管化复合组织异体移植(VCA)是移植外科领域中一个新兴的领域。尽管总体结果是积极的,但VCA会带来与手术及后续免疫抑制相关的多种并发症风险。移植后淋巴组织增生性疾病(PTLD)是实体器官和造血干细胞移植后发生的一组异质性淋巴组织增生性疾病。本文介绍了一例双侧上肢移植后发生PTLD的患者,并对VCA后所有已知的PTLD病例进行了综述,重点关注该人群独特的流行病学、临床表现和治疗方法。