激光针灸与利拉鲁肽治疗肥胖症的多机构回顾性队列研究

Laser Acupuncture versus Liraglutide in Treatment of Obesity: A Multi-Institutional Retrospective Cohort Study.

作者信息

Yu Wen-Lin, Liao Yu-Ning, Yang Tsung-Hsien, Yang Ching-Wei, Kao Ting-I, Lee Pai-Wei, Hsu Chiu-Yi, Huang Jhen-Ling, Huang Yu-Tung, Chen Hsing-Yu

机构信息

Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.

School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

出版信息

Healthcare (Basel). 2024 Jun 26;12(13):1279. doi: 10.3390/healthcare12131279.

BACKGROUND

Obesity is a global concern, driving the search for alternative treatments beyond lifestyle changes and medications. Laser acupuncture (LA) shows promise in obesity management, yet few studies compare it with FDA-approved medications. This study aimed to assess and compare LA's impact with liraglutide on weight reduction in obese individuals.

METHODS

Data from the Chang Gung Research Database (CGRD) (2013-2018) were analyzed. Primary outcomes included changes in body weight and BMI within 180 days, with secondary outcomes measuring the proportion achieving 5%, 10%, and 15% weight loss. Adverse events were also assessed.

RESULTS

Of 745 subjects (173 LA users, 572 liraglutide users), LA users lost more weight by day 180 (5.82 ± 4.39 vs. 2.38 ± 5.75 kg; < 0.001) and had a greater BMI reduction (-2.27 ± 1.73 vs. -0.93 ± 2.25 kg/m; < 0.001). More LA users achieved 5% and 10% weight loss compared to liraglutide users (64.2% vs. 22.7%, 26.6% vs. 4.2%; all < 0.001). After balancing baseline differences, LA's benefits remained significant. No adverse events were reported with LA.

CONCLUSIONS

LA may offer superior weight reduction compared to liraglutide. Future studies should explore LA alone or in combination with liraglutide for obesity management.

背景

肥胖是一个全球性问题，促使人们寻求除生活方式改变和药物治疗之外的其他治疗方法。激光针灸在肥胖管理方面显示出前景，但很少有研究将其与美国食品药品监督管理局（FDA）批准的药物进行比较。本研究旨在评估并比较激光针灸与利拉鲁肽对肥胖个体体重减轻的影响。

方法

分析了长庚研究数据库（CGRD）（2013 - 2018年）中的数据。主要结局包括180天内体重和体重指数（BMI）的变化，次要结局衡量实现体重减轻5%、10%和15%的比例。还评估了不良事件。

结果

在745名受试者中（173名激光针灸使用者，572名利拉鲁肽使用者），激光针灸使用者在第180天时体重减轻更多（5.82±4.39 vs. 2.38±5.75千克；<0.001），BMI降低幅度更大（-2.27±1.73 vs. -0.93±2.25千克/米；<0.001）。与利拉鲁肽使用者相比，更多激光针灸使用者实现了5%和10%的体重减轻（64.2% vs. 22.7%，26.6% vs. 4.2%；均<0.001）。在平衡基线差异后，激光针灸的益处仍然显著。激光针灸未报告不良事件。