噬菌体展示技术在生物标志物鉴定中的应用，重点是非癌症疾病。
Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases.
机构信息
Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.
Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
出版信息
Molecules. 2024 Jun 25;29(13):3002. doi: 10.3390/molecules29133002.
In recent years, phage display technology has become vital in clinical research. It helps create antibodies that can specifically bind to complex antigens, which is crucial for identifying biomarkers and improving diagnostics and treatments. However, existing reviews often overlook its importance in areas outside cancer research. This review aims to fill that gap by explaining the basics of phage display and its applications in detecting and treating various non-cancerous diseases. We focus especially on its role in degenerative diseases, inflammatory and autoimmune diseases, and chronic non-communicable diseases, showing how it is changing the way we diagnose and treat illnesses. By highlighting important discoveries and future possibilities, we hope to emphasize the significance of phage display in modern healthcare.
近年来，噬菌体展示技术在临床研究中变得至关重要。它有助于创建能够特异性结合复杂抗原的抗体，这对于识别生物标志物以及改善诊断和治疗方法非常重要。然而，现有的综述往往忽略了它在癌症研究以外的领域的重要性。本文旨在通过解释噬菌体展示的基础知识及其在检测和治疗各种非癌症疾病中的应用来填补这一空白。我们特别关注它在退行性疾病、炎症和自身免疫性疾病以及慢性非传染性疾病中的作用，展示它如何改变我们诊断和治疗疾病的方式。通过强调重要的发现和未来的可能性，我们希望强调噬菌体展示在现代医疗保健中的重要性。
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