Dutta Pritam, Atiya Ayisha, Vittal Smita, Ambika S, Hussaindeen Jameel Rizwana
Sankara Nethralaya Academy, Tamil Nadu Dr. M.G.R Medical University, Chennai, Tamil Nadu, India.
Department of Binocular Vision and Neuro-Optometry, Sankara Nethralaya, Chennai, Tamil Nadu, India.
Taiwan J Ophthalmol. 2023 May 23;14(2):248-255. doi: 10.4103/tjo.TJO-D-22-00169. eCollection 2024 Apr-Jun.
To measure the pupillary dynamics and accommodative response in individuals with mild traumatic brain injury (mTBI) as compared to age-matched controls.
This prospective comparative study was carried out at the neuro-optometry clinic of a tertiary eye care hospital. Sixty-three subjects with a history of mTBI and ninety age-matched controls were enrolled in this study. Subjects in the age range of 18-35 years were included in the study. A comprehensive neuro-optometric assessment was performed followed by pupillary dynamics and accommodation response measurements using NeurOptics® pupillary light reflex™-3000 and Grand-Seiko WAM-5500 binocular accommodation auto ref/keratometer | shigiya machinery works LTD.
A statistically significant difference was noticed for constriction percentage (%): 32.73 ± 9.20 versus 39.93 ± 7.36 ( < 0.001), average constriction velocity (mm/s): 2.24 ± 0.85 versus 2.62 ± 0.68 ( = 0.002), maximum constriction velocity (mm/s): 3.82 ± 1.33 versus 4.42 ± 0.93 ( = 0.004) and T75 (recovery period to 75% of the baseline pupillary diameter in sec): 1.38 ± 0.36 versus 2.0 ± 0.82 ( < 0.001) in mTBI compared to age-matched controls. A statistically significant difference was noted for accommodative response (in D) as well as in the sample as compared to age-matched controls: -1.12 ± 0.64 versus - 1.39 ± 0.47 ( < 0.001).
Pupillary constriction velocities and accommodative response are significantly affected in mTBI. These findings have important clinical implications in being able to understand the visual symptoms following an mTBI.
与年龄匹配的对照组相比，测量轻度创伤性脑损伤（mTBI）患者的瞳孔动态变化和调节反应。
这项前瞻性比较研究在一家三级眼科护理医院的神经验光诊所进行。本研究纳入了63名有mTBI病史的受试者和90名年龄匹配的对照组。研究纳入了年龄在18 - 35岁之间的受试者。进行了全面的神经验光评估，随后使用NeurOptics®瞳孔光反射™ - 3000和Grand - Seiko WAM - 5500双目调节自动验光仪/角膜曲率计|志屋机械工程有限公司测量瞳孔动态变化和调节反应。
与年龄匹配的对照组相比，mTBI患者在收缩百分比（%）方面存在统计学显著差异：32.73±9.20对39.93±7.36（<0.001），平均收缩速度（mm/s）：2.24±0.85对2.62±0.68（=0.002），最大收缩速度（mm/s）：3.82±1.33对4.42±0.93（=0.004）以及T75（恢复到基线瞳孔直径75%的时间，单位为秒）：1.38±0.3对2.0±0.82（<0.001）。与年龄匹配的对照组相比，在调节反应（单位为屈光度）以及样本中也发现了统计学显著差异：-1.12±0.64对-1.39±0.47（<0.001）。
mTBI患者的瞳孔收缩速度和调节反应受到显著影响。这些发现对于理解mTBI后的视觉症状具有重要的临床意义。
