发热儿童易发生惊厥与其营养状态和炎症相关的预后营养指数与中性粒细胞与淋巴细胞比值的初步研究

A preliminary study on the association between prognostic nutritional index and neutrophil-to-lymphocyte ratio with nutritional status and inflammation in febrile children's susceptibility to seizures.

机构信息

Balıkesir University, Faculty of Medical, Department of Pediatrics, Division of Pediatric Neurology - Balıkesir, Turkey.

Balıkesir University, Faculty of Medical, Department of Gynecology and Obstetrics, Division of Perinatology - Balıkesir, Turkey.

出版信息

Rev Assoc Med Bras (1992). 2024 Jul 19;70(7):e20240166. doi: 10.1590/1806-9282.20240166. eCollection 2024.

DOI:10.1590/1806-9282.20240166

PMID:39045938

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11262348/

Abstract

OBJECTIVE

The aim of this study was to evaluate the association between nutritional status, inflammation, and susceptibility to seizures in febrile children.

METHODS

This observational single-center study was carried out from January 2020 to December 2023 with 324 children aged 6 months and 6 years; 106 were diagnosed with febrile seizure, 108 were febrile children, and 110 were healthy controls. The prognostic nutritional index and neutrophil-to-lymphocyte ratio were calculated, and the cutoff threshold was established through receiver operating characteristics. The study utilized correlation and univariate-multivariate logistic regression analysis. The comparison between simple and complex febrile seizure was conducted to analyze differences.

RESULTS

The optimal cutoff values were identified as 61.25 for prognostic nutritional index and 1.04 for neutrophil-to-lymphocyte ratio. Our findings showed a significant negative association between febrile seizure and platelet count, high C-reactive protein, and high ferritin levels. Additionally, the febrile seizure group showed a significant positive correlation with high neutrophil-to-lymphocyte ratio values (≥1.04) and body temperature (≥38). Our findings revealed that high neutrophil-to-lymphocyte ratio, high C-reactive protein, and age less than 18 months were independently associated with seizure susceptibility in febrile children.

CONCLUSION

High neutrophil-to-lymphocyte ratio values and low prognostic nutritional index scores may serve as novel surrogate independent factors for seizure susceptibility in febrile children. Febrile children who are less than 18 months old are more prone to experience seizures than older febrile children. Moreover, there was a correlation between febrile seizures and elevated C-reactive protein levels and neutrophil-to-lymphocyte ratio values.

摘要

目的

本研究旨在评估营养状况、炎症与热性惊厥儿童易感性之间的关系。

方法

本观察性单中心研究于 2020 年 1 月至 2023 年 12 月进行，共纳入 324 名 6 个月至 6 岁的儿童；其中 106 例被诊断为热性惊厥，108 例为热性儿童，110 例为健康对照组。计算预后营养指数和中性粒细胞与淋巴细胞比值，并通过受试者工作特征确定截断值。研究采用相关性和单变量多变量逻辑回归分析。进行简单性和复杂性热性惊厥比较，分析差异。

结果

确定预后营养指数的最佳截断值为 61.25，中性粒细胞与淋巴细胞比值的最佳截断值为 1.04。我们的研究结果表明，热性惊厥与血小板计数、高 C 反应蛋白和高铁蛋白水平呈显著负相关。此外，热性惊厥组与高中性粒细胞与淋巴细胞比值（≥1.04）和体温（≥38）呈显著正相关。我们的研究结果表明，高中性粒细胞与淋巴细胞比值、高 C 反应蛋白和年龄小于 18 个月与热性儿童的易发性有关。