Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
The Collaborative Innovation Center of Tissue Damage Repair and Regenerative Medicine of Zunyi Medical University, Zunyi, Guizhou, China.
Cancer Gene Ther. 2024 Nov;31(11):1611-1618. doi: 10.1038/s41417-024-00782-8. Epub 2024 Jul 24.
The incidence of hepatocellular carcinoma (HCC) has continued to increase annually worldwide, and HCC has become a common cause of cancer-related death. Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor. In recent years, the role of ion channels in the pathogenesis of diseases has become a hot topic. In normal liver tissue, ion channels and transporters maintain water and electrolyte balance and acid‒base homeostasis. However, dysfunction of these ion channels and transporters can lead to the development and progression of HCC, and thus these ion channels and transporters are expected to become new therapeutic targets. In this review, ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed.
肝细胞癌（HCC）的发病率在全球范围内持续逐年增加，HCC 已成为癌症相关死亡的常见原因。尽管人们对 HCC 发生的分子机制有了很大的了解，但 HCC 的治疗仍然是一个相当大的挑战。因此，HCC 患者的生存率和预后仍然极差。近年来，离子通道在疾病发病机制中的作用已成为热门话题。在正常肝组织中，离子通道和转运体维持水和电解质平衡以及酸碱平衡。然而，这些离子通道和转运体的功能障碍可导致 HCC 的发生和发展，因此这些离子通道和转运体有望成为新的治疗靶点。本文综述了与 HCC 相关的离子通道和转运体，并提出了新的有效治疗的潜在靶点。
