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利用宿主和载体:病毒促进传播的策略。

Exploiting hosts and vectors: viral strategies for facilitating transmission.

机构信息

New Cornerstone Science Laboratory, Tsinghua-Peking Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084, China.

Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong, 518000, China.

出版信息

EMBO Rep. 2024 Aug;25(8):3187-3201. doi: 10.1038/s44319-024-00214-6. Epub 2024 Jul 24.

Abstract

Viruses have developed various strategies to ensure their survival and transmission. One intriguing strategy involves manipulating the behavior of infected arthropod vectors and hosts. Through intricate interactions, viruses can modify vector behavior, aiding in crossing barriers and improving transmission to new hosts. This manipulation may include altering vector feeding preferences, thus promoting virus transmission to susceptible individuals. In addition, viruses employ diverse dissemination methods, including cell-to-cell and intercellular transmission via extracellular vesicles. These strategies allow viruses to establish themselves in favorable environments, optimize replication, and increase the likelihood of spreading to other individuals. Understanding these complex viral strategies offers valuable insights into their biology, transmission dynamics, and potential interventions for controlling infections. Unraveling interactions between viruses, hosts, and vectors enables the development of targeted approaches to effectively mitigate viral diseases and prevent transmission.

摘要

病毒已经发展出各种策略来确保其生存和传播。一种有趣的策略涉及操纵感染节肢动物媒介和宿主的行为。通过复杂的相互作用,病毒可以改变媒介的行为,帮助跨越障碍并提高向新宿主的传播能力。这种操纵可能包括改变媒介的取食偏好,从而促进病毒向易感个体传播。此外,病毒还采用多种传播方法,包括通过细胞间和细胞外小泡进行细胞间传播。这些策略使病毒能够在有利的环境中建立自己的地位,优化复制,并增加传播给其他个体的可能性。了解这些复杂的病毒策略为它们的生物学、传播动态以及控制感染的潜在干预措施提供了有价值的见解。揭示病毒、宿主和媒介之间的相互作用,使我们能够开发出有针对性的方法来有效减轻病毒疾病并防止传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c92e/11315993/2bf9dbce0146/44319_2024_214_Fig1_HTML.jpg

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