Changzhou Key Laboratory of Molecular Diagnostics and Precision Cancer Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, China; Changzhou Medical Center, Nanjing Medical University, Changzhou, China.
Changzhou Key Laboratory of Molecular Diagnostics and Precision Cancer Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, China; Department of Laboratory Medicine, Wujin Hospital Affiliated with Jiangsu University, Jiangsu University, Changzhou, China.
Biomed Pharmacother. 2024 Sep;178:117182. doi: 10.1016/j.biopha.2024.117182. Epub 2024 Jul 24.
Cuproptosis is a novel form of regulated cell death, which plays an important role in the physiological and pathological processes of the human body. Despite the increasing research on cuproptosis-related genes (CRGs) and their correlation with diseases, the pathogenesis of cuproptosis-related diseases remains unclear. Furthermore, there is a lack of reviews on the emerging technologies for regulating cuproptosis in disease treatment. This study delves into the copper-induced cell death mechanism, distinguishing cuproptosis from mechanisms like oxidative stress, glutathione synthesis inhibition, and ubiquitin-proteasome system inhibition. Several long-standing mysteries of diseases such as Wilson's disease and Menkes disease may be attributed to the occurrence of cuproptosis. In addition, we also review the detection indicators related to cuproptosis, providing targets for the diagnosis of cuproptosis-related diseases, and summarize the application value of cuproptosis in tumor therapy to better elucidate the impact of copper in cell death and diseases, and thus to promote the application prospects and possible strategies of cuproptosis-related substances, such as copper ion chelators, copper ion carriers, and copper nanomaterials, in disease therapy.
铜死亡是一种新的细胞程序性死亡形式，在人体的生理和病理过程中起着重要作用。尽管与铜死亡相关的基因（CRGs）及其与疾病的相关性的研究不断增加，但铜死亡相关疾病的发病机制仍不清楚。此外，在疾病治疗中调节铜死亡的新技术缺乏综述。本研究深入探讨了铜诱导的细胞死亡机制，将铜死亡与氧化应激、谷胱甘肽合成抑制和泛素-蛋白酶体系统抑制等机制区分开来。Wilson 病和 Menkes 病等一些长期存在的疾病之谜可能归因于铜死亡的发生。此外，我们还回顾了与铜死亡相关的检测指标，为铜死亡相关疾病的诊断提供了目标，并总结了铜死亡在肿瘤治疗中的应用价值，以更好地阐明铜在细胞死亡和疾病中的作用，从而促进铜死亡相关物质（如铜离子螯合剂、铜离子载体和铜纳米材料）在疾病治疗中的应用前景和可能策略。
