Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29007 Malaga, Spain.
Instituto de Investigación Biomédica de Málaga (IBIMA), Plataforma Bionand, 29010 Malaga, Spain.
Nutrients. 2024 Jul 11;16(14):2221. doi: 10.3390/nu16142221.
The aim of our study is to determine if there is an association between phase angle obtained by bioelectrical impedance analysis (BIA) and mortality in older patients with fragility hip fractures. A prospective study of patients over 65 years old and hospitalized with a diagnosis of hip fracture was conducted. BIA was performed 24 to 48 h after surgery. Mortality was recorded, and the optimal phase angle cut-off value for predicting mortality was determined by using receiver operating characteristic (ROC) curves. A total of 262 patients were included. Of the patients studied, 10 (3.8%), 21 (8%), 39 (14.9%) and 53 (20.2%) died at 1, 3, 6 and 12 months after surgery, respectively. The phase angle cut-off for mortality at 12 months was 4.05° in women and 4.65° in men. A total of 94 patients (35.9%) were considered to have a low phase angle. After adjustment for possible confounders, mortality in patients with a low phase angle was 5.1 times higher at 1 month, 3.1 times higher at 3 months, 2.9 times higher at 6 months, and 2.8 times higher at 12 months. Phase angle is associated with prognosis in patients admitted for hip fracture regardless of age and comorbidities and can be positioned as a prognostic tool for mortality at 1, 3, 6 and 12 months.
我们的研究目的是确定生物电阻抗分析(BIA)得出的相位角与脆弱性髋部骨折老年患者的死亡率之间是否存在关联。对 65 岁以上因髋部骨折住院的患者进行了前瞻性研究。BIA 在手术后 24 至 48 小时进行。记录死亡率,并通过接收者操作特征(ROC)曲线确定预测死亡率的最佳相位角截断值。共纳入 262 例患者。研究中,10 例(3.8%)、21 例(8%)、39 例(14.9%)和 53 例(20.2%)患者分别在手术后 1、3、6 和 12 个月时死亡。女性 12 个月时的死亡相位角截断值为 4.05°,男性为 4.65°。共有 94 例(35.9%)患者被认为相位角较低。在调整可能的混杂因素后,低相位角患者在 1 个月时的死亡率高出 5.1 倍,在 3 个月时高出 3.1 倍,在 6 个月时高出 2.9 倍,在 12 个月时高出 2.8 倍。相位角与髋部骨折入院患者的预后相关,无论年龄和合并症如何,均可作为 1、3、6 和 12 个月死亡率的预后工具。