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炎症性肠病患者临床缓解期的饮食状况:一项初步研究。

Dietary Profile of Patients with Inflammatory Bowel Disease in Clinical Remission-A Preliminary Study.

机构信息

Laboratory of Nutrition and Metabolic Surgery (LIM-35), Department of Gastroenterology, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de São Paulo, São Paulo 13563-120, Brazil.

Department of Gastroenterology, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de São Paulo, São Paulo 13563-120, Brazil.

出版信息

Nutrients. 2024 Jul 11;16(14):2227. doi: 10.3390/nu16142227.

Abstract

Imbalanced dietary intake is associated with the development of inflammatory bowel diseases (IBDs) and is often observed during the active phases of Crohn's disease (CD) and ulcerative colitis (UC). Cumulative data also suggest the potential for dietary manipulation in avoiding IBD relapse. However, there is a paucity of dietary data from patients in clinical remission to guide such an approach. Our study aimed to characterize the dietary pattern and adequacy of patients with IBD in clinical remission. Data on dietary intake (three alternate 24 h food records) were collected from 40 patients with IBD (20 CD and 20 UC) and 45 gender-matched healthy controls (HC). Statistical comparisons between patients and controls employed Student's -test, Mann-Whitney U, chi-squared, and Fisher's exact tests. The adequacy of dietary intake of IBD patients was further studied by assessing the nutrient inadequacy prevalence, estimated using the Dietary Reference Intakes (DRI) framework and the Estimated Average Requirement (EAR) parameter. We observed significant dietary imbalances among patients with IBD compared to the HC group, marked by disparities in both macronutrient and micronutrient intakes. Inadequacies with frequencies >80% were observed for the ingestion of total fiber and 13 micronutrients in IBD patients. Our preliminary findings suggest that imbalanced dietary intake is also characteristic among individuals with IBD during clinical remission, corroborating the need for dietary interventions in this population.

摘要

饮食摄入不平衡与炎症性肠病 (IBD) 的发展有关,并且在克罗恩病 (CD) 和溃疡性结肠炎 (UC) 的活动期经常观察到。累积数据还表明,通过饮食控制来避免 IBD 复发是有潜力的。然而,在临床缓解期的患者中,关于饮食的数据很少,无法指导这种方法。我们的研究旨在描述处于临床缓解期的 IBD 患者的饮食模式和充足性。从 40 名 IBD 患者(20 名 CD 和 20 名 UC)和 45 名性别匹配的健康对照者(HC)中收集了关于饮食摄入的(三个交替的 24 小时食物记录)数据。使用学生 t 检验、Mann-Whitney U 检验、卡方检验和 Fisher 精确检验对患者和对照组之间的数据进行统计比较。通过评估基于膳食参考摄入量(DRI)框架和估计平均需求量(EAR)参数的营养素不足的流行率,进一步研究了 IBD 患者的饮食摄入充足性。与 HC 组相比,IBD 患者的饮食存在明显的不平衡,表现在宏量营养素和微量营养素的摄入都存在差异。IBD 患者的总纤维和 13 种微量营养素的摄入量不足频率>80%。我们的初步发现表明,在临床缓解期的 IBD 患者中,饮食摄入不平衡也是特征性的,这证实了在该人群中进行饮食干预的必要性。

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