一种新型营养补充剂可降低健康个体进食富含碳水化合物的餐食或蔗糖饮料后的餐后血糖和胰岛素水平：一项随机、安慰剂对照、交叉喂养研究。

A Novel Nutraceutical Supplement Lowers Postprandial Glucose and Insulin Levels upon a Carbohydrate-Rich Meal or Sucrose Drink Intake in Healthy Individuals-A Randomized, Placebo-Controlled, Crossover Feeding Study.

机构信息

Center of Excellence for Clinical Microbiome Research, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, India.

Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar 751019, India.

出版信息

Nutrients. 2024 Jul 11;16(14):2237. doi: 10.3390/nu16142237.

DOI:10.3390/nu16142237

PMID:39064681

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11280099/

Abstract

BACKGROUND

Alkaloid- and polyphenol-rich white mulberry leaf and apple peel extracts have been shown to have potential glucose-lowering effects, benefitting the control of postprandial blood glucose levels. This study aimed to determine the effect of the combination of peel and leaf extracts (GLUBLOC) on postprandial blood glucose and insulin-lowering effects in healthy adults after a carbohydrate-rich meal or sucrose drink intake.

METHODS

This study was designed as a randomized, crossover, single-blinded clinical trial. Out of 116 healthy participants, 85 subjects (aged 18-60 years) completed the day 1 and 5 crossover study. On day 1, subjects were supplemented with a placebo or GLUBLOC tablet 10 min before the carbohydrate-rich meal (300 g of tomato rice) or sucrose drink intake (75 g of sucrose dissolved in 300 mL water). On day 5, the treatments were crossed over, and the same diet was followed. Postprandial blood glucose and insulin levels were measured on days 1 and 5 (baseline 0, post-meal 30, 60, 90, and 120 min). Differences in iAUC, Cmax, and Tmax were determined between the placebo and GLUBLOC-treated cohorts.

RESULTS

Significant changes in total iAUC (0-120 min), Cmax, and Tmax of postprandial blood glucose and insulin levels were noticed upon GLUBLOC supplementation. The percentage reduction in the iAUC of blood glucose levels was 49.78% (iAUC) and 43.36% (iAUC), respectively, compared with the placebo in the sucrose drink intake study. Similarly, there was a 41.13% (iAUC) and 20.26% (iAUC) glucose-lowering effect compared with the placebo in the carbohydrate-rich meal intake study.

CONCLUSIONS

Premeal supplementation with GLUBLOC significantly reduced the postprandial surge in blood glucose and insulin levels after a carbohydrate-rich meal or sucrose drink intake over 120 min in healthy individuals. This study proves that GLUBLOC can manage steady postprandial blood glucose levels.

摘要

背景

富含生物碱和多酚的桑叶和苹果皮提取物已被证明具有潜在的降血糖作用，有益于控制餐后血糖水平。本研究旨在确定富含碳水化合物的餐或蔗糖饮料摄入后，复合桑叶和苹果皮提取物（GLUBLOC）对健康成年人餐后血糖和胰岛素降低的影响。

方法

本研究设计为随机、交叉、单盲临床试验。在 116 名健康参与者中，85 名受试者（年龄 18-60 岁）完成了第 1 天和第 5 天的交叉研究。第 1 天，受试者在摄入富含碳水化合物的餐（300 克番茄米饭）或蔗糖饮料（75 克蔗糖溶于 300 毫升水）前 10 分钟补充安慰剂或 GLUBLOC 片。第 5 天，进行交叉处理，并遵循相同的饮食。在第 1 天和第 5 天测量餐后血糖和胰岛素水平（基线 0 ，餐后 30 ，60 ，90 和 120 分钟）。在安慰剂和 GLUBLOC 治疗组之间确定 iAUC ，Cmax 和 Tmax 的差异。

结果

GLUBLOC 补充后，餐后血糖和胰岛素水平的总 iAUC （0-120 分钟），Cmax 和 Tmax 均发生显著变化。与蔗糖饮料摄入研究中的安慰剂相比，GLUBLOC 组的血糖水平 iAUC 降低了 49.78%（iAUC）和 43.36%（iAUC）。同样，在富含碳水化合物的餐摄入研究中，与安慰剂相比，GLUBLOC 组的血糖降低了 41.13%（iAUC）和 20.26%（iAUC）。