Habib Syed Shahid, Al-Khlaiwi Thamir, Al-Khliwi Huthayfah, Habib Syed Mohammad, Habib Syed Abubakar, Habib Syed Hamid, Khan Adeena
Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
College of Medicine, Sulaiman Al Rajhi University, Al Bukayriah, Saudi Arabia.
J Family Med Prim Care. 2024 Jul;13(7):2741-2745. doi: 10.4103/jfmpc.jfmpc_1896_23. Epub 2024 Jun 28.
The correlation of adiponectin and serum tumor necrosis factor alpha (TNFα) with glucometabolic parameters in diabetes mellitus (DM) needs further studies. We aimed in this study to evaluate the relationship between adiponectin and TNFα with glucometabolic parameters in patients with type 2 DM (T2DM).
We conducted a cross-sectional study in the Department of Physiology, College of Medicine, King Saud University, Saudi Arabia. The sample size was 117 from the diabetes clinic of King Abdul-Aziz University hospital through the convenience sampling technique. Subjects were grouped into control (healthy) subjects (53) with no chronic diseases and the diabetic group (64) with confirmed T2DM. Socio-demographic data were collected along with the serum blood sample to analyze the variables.
Adiponectin was significantly high in healthy subjects compared to the diabetic group (control: 14.4 ± 4.3, T2DM: 11.0 ± 4.1, = 0.000), while TNFα was higher in the T2DM group (7.8 ± 2.7) than in the control group (6.6 ± 2.9, = 0.024). TNFα was negatively correlated with adiponectin in the control group (-0.279) and in diabetic subjects (-0.311) and positively correlated with HbA1c in the diabetic group (0.319) and triglycerides (0.252). Adiponectin was positively correlated with HDL in the control group (0.252) and in diabetic subjects (0.326). There was an inverse correlation between TNFα and adiponectin.
Adiponectin is higher in healthy subjects than in diabetic patients, while TNFα is higher in diabetic patients. In addition, adiponectin is positively correlated with HDL in healthy as well as diabetic patients. TNFα is positively correlated with HbA1c and triglycerides.
脂联素和血清肿瘤坏死因子α（TNFα）与糖尿病（DM）糖代谢参数之间的相关性有待进一步研究。本研究旨在评估2型糖尿病（T2DM）患者脂联素和TNFα与糖代谢参数之间的关系。
我们在沙特阿拉伯国王沙特大学医学院生理学系进行了一项横断面研究。通过便利抽样技术，从阿卜杜勒-阿齐兹国王大学医院糖尿病诊所选取了117名样本。受试者分为无慢性病的对照组（健康）受试者（53名）和确诊为T2DM的糖尿病组（64名）。收集社会人口统计学数据以及血清血样以分析变量。
与糖尿病组相比，健康受试者的脂联素显著更高（对照组：14.4±4.3，T2DM组：11.0±4.1，P = 0.000），而T2DM组的TNFα（7.8±2.7）高于对照组（6.6±2.9，P = 0.024）。在对照组（-0.279）和糖尿病受试者（-0.311）中，TNFα与脂联素呈负相关，在糖尿病组中与糖化血红蛋白（0.319）和甘油三酯（0.252）呈正相关。在对照组（0.252）和糖尿病受试者（0.326）中，脂联素与高密度脂蛋白呈正相关。TNFα与脂联素呈负相关。
健康受试者的脂联素高于糖尿病患者，而糖尿病患者的TNFα更高。此外，健康和糖尿病患者的脂联素均与高密度脂蛋白呈正相关。TNFα与糖化血红蛋白和甘油三酯呈正相关。
