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依博加因治疗引发的多次心脏骤停:一例报告

Multiple Episodes of Cardiac Arrest Induced by Treatment With Ibogaine: A Case Report.

作者信息

Mestre David, Paula Alexandra, Gil Francisco P, Vaz José

机构信息

Intensive Care Unit, Hospital José Joaquim Fernandes, Beja, PRT.

出版信息

Cureus. 2024 Jun 29;16(6):e63487. doi: 10.7759/cureus.63487. eCollection 2024 Jun.

Abstract

Opioid dependence is a common problem, and therapeutic alternatives are scarce and ineffective. Ibogaine, illegal in several countries, has been reported as a possible therapy in alternative clinics and it is also used as a recreational drug, despite its cardiotoxic potential, including QT prolongation. We report a case of long QT leading to multiple episodes of cardiac arrest after a single dose of ibogaine (200mg, 2.6mg/Kg) in a patient without structural heart disease. This case highlights the fact that even low doses of ibogaine can be lethal and warns us about the consequences of its use.

摘要

阿片类药物依赖是一个常见问题,而治疗选择稀缺且无效。伊博格碱在多个国家属于非法药物,在替代诊所中被报道为一种可能的治疗方法,并且尽管它有心脏毒性风险,包括QT间期延长,仍被用作消遣性药物。我们报告了一例在无结构性心脏病的患者中,单次服用伊博格碱(200mg,2.6mg/kg)后出现长QT间期并导致多次心脏骤停的病例。该病例凸显了即使低剂量的伊博格碱也可能致命这一事实,并警示我们其使用后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5821/11287021/98029461567d/cureus-0016-00000063487-i01.jpg

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