[Effect of glucose metabolic products on the growth of a recombinant Escherichia coli strain--a superproducer of DNA-polymerase].

The dynamics of glucose metabolites production by Escherichia coli CM 5199 was studied under the conditions of batch and continuous cultivation. Acetate and ethanol were shown to be accumulated in the cultural broth in considerable amounts, and the rate of their synthesis was directly proportional to the specific growth rate of the culture. Acetate inhibited E. coli growth as was found in experiments conducted in a turbidostat regimen. As a result, the specific growth rate of the strain decreased during both batch and continuous cultivation.