Division of Immunology, Boston Children's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Adv Exp Med Biol. 2024;1448:409-425. doi: 10.1007/978-3-031-59815-9_28.
Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infections in children. This syndrome manifests about a month after the initial viral infection and is characterized by fever, multiorgan dysfunction, and systemic inflammation. This chapter will review the emergence, epidemiology, clinical characteristics, diagnosis, pathophysiology, immunomodulatory treatment, prognosis, outcomes, and prevention of MIS-C. While the pathophysiology of MIS-C remains to be defined, it is a post-infection, hyperinflammatory syndrome of childhood with elevated inflammatory cytokines.
儿童多系统炎症综合征（MIS-C）是儿童 SARS-CoV-2 感染的严重并发症。该综合征在初始病毒感染后约一个月出现，表现为发热、多器官功能障碍和全身炎症。本章将回顾 MIS-C 的出现、流行病学、临床特征、诊断、病理生理学、免疫调节治疗、预后、结局和预防。虽然 MIS-C 的病理生理学仍有待确定，但它是一种儿童感染后、炎症细胞因子升高的超炎症综合征。
