Etiological, sociodemographic and clinical characteristics of sexually transmitted infections and resistance in Shenzhen: a multicenter cross-sectional study in China.

INTRODUCTION

This study aims to determine the etiological, sociodemographic, and clinical characteristics of STIs, and the level of resistance in in Shenzhen, a representative first-tier city of southern China.

METHODS

A multicenter cross-sectional study was conducted and 7886 sexually active participants attending STI-related departments were involved from 22 hospitals. Nine STI-related organisms including , , , , HSV-1, HSV-2, , , and were screened.

RESULTS

Being single or divorced was associated with increased detection of , C, , HSV-1, HSV-2 and . Lower education level was associated with increased detection of , HSV-2 and . No insurance coverage was an independent risk factor for , and positivity. Three resistance-determining regions related to macrolide and fluoroquinolone were sequenced in 154 positive samples, among which 90.3% harbored mutations related to macrolide or fluroquinolone resistance and 67.5% were multidrug-resistant . A2072G in 23S rRNA and Ser83Ile in were the most common mutations. was associated with manifestations of bacterial vaginosis in female and epididymitis in male.

CONCLUSIONS

Single or divorced individuals, those with lower education level and individuals without insurance are higher-risk key populations for STIs. The prevalence of antimicrobial-resistant in Shenzhen is high. Detection of increased significantly with lower education level and no health insurance coverage, and it is associated with bacterial vaginosis or epididymitis, indicating that deserves further attention.