糖尿病与肝硬化患者自发性细菌性腹膜炎风险的关系：系统评价和荟萃分析。
Diabetes mellitus and the risk of spontaneous bacterial peritonitis in patients with liver cirrhosis: a systematic review and meta-analysis.
机构信息
From the Department of Public Health, Makkah Branch of the Ministry of Health, Makkah, Saudi Arabia.
From the Primary Healthcare Centers, Makkah Health Clusters, Makkah, Saudi Arabia.
出版信息
Ann Saudi Med. 2024 Jul-Aug;44(4):272-287. doi: 10.5144/0256-4947.2024.272. Epub 2024 Aug 1.
BACKGROUND
Spontaneous bacterial peritonitis (SBP) represents a critical and potentially lethal condition that typically develops in individuals with liver cirrhosis. This meta-analysis aimed to assess diabetes mellitus (DM) as a risk factor for SBP in liver cirrhotic patients.
METHODS
Following PRISMA guidelines, fifteen studies were included, for a total of 76 815 patients. The risk of bias was assessed using the Newcastle-Ottawa scale (NOS). We represented the results as risk ratios (RR) with the corresponding 95% confidence intervals (CI) using RevMan software. Additionally, we pooled the hazard ratios (HR) for developing SBP in patients with DM from the included studies.
RESULTS
The meta-analysis shows a significantly increased risk of SBP in cirrhotic patients with DM (HR: 1.26; 95% CI [1.05-1.51], =.01; HR: 1.70; 95% CI [1.32-2.18], <.001).
CONCLUSIONS
The study signifies that DM is an independent risk factor for SBP, emphasizing the need for targeted preventive measures in this specific population.
背景
自发性细菌性腹膜炎（SBP）是一种严重且潜在致命的疾病，通常发生在肝硬化患者中。本荟萃分析旨在评估糖尿病（DM）是否为肝硬化患者发生 SBP 的危险因素。
方法
根据 PRISMA 指南，共纳入了 15 项研究，总计 76815 名患者。使用纽卡斯尔-渥太华量表（NOS）评估偏倚风险。我们使用 RevMan 软件表示结果为风险比（RR）及其相应的 95%置信区间（CI）。此外，我们还汇总了纳入研究中 DM 患者发生 SBP 的风险比（HR）。
结果
荟萃分析显示，糖尿病会显著增加肝硬化患者发生 SBP 的风险（HR：1.26；95%CI [1.05-1.51]，.01；HR：1.70；95%CI [1.32-2.18]，<.001）。
结论
该研究表明 DM 是 SBP 的一个独立危险因素，强调在这一特定人群中需要采取有针对性的预防措施。
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